UCP3 Ablation Exacerbates High-Salt Induced Cardiac Hypertrophy and Cardiac Dysfunction.

Abstract

BACKGROUND/AIMS:

Excessive salt intake and left ventricular hypertrophy (LVH) are both critical for the development of hypertension and heart failure. The uncoupling protein 3 (UCP3) plays a cardio-protective role in early heart failure development. However, the potential role for UCP3 in salt intake and LVH is unclear.

METHODS:

UCP3-/- and C57BL/6 mice were placed on either a normal-salt (NS, 0.5%) or a high-salt (HS, 8%) diet for 24 weeks. The cardiac function, endurance capacity, energy expenditure, and mitochondrial functional capacity were measured in each group.

RESULTS:

Elevated blood pressure was only observed in HS-fed UCP3-/- mice. High salt induced cardiac hypertrophy and dysfunction were observed in both C57BL/6 and UCP3-/- mice. However, the cardiac lesions were more profound in HS-fed UCP3-/- mice. Furthermore, HS-fed UCP3-/-mice experienced more severe mitochondrial respiratory dysfunction compared with HS-fed C57BL/6 mice, represented by the decreased volume of oxygen consumption and heat production at the whole-body level.

CONCLUSION:

UCP3 protein was involved in the incidence of high-salt induced hypertension and the progression of cardiac dysfunction in the early stages of heart failure. UCP3 ablation exacerbated high-salt-induced cardiac hypertrophy and cardiac dysfunction.

• Authors: Hongmei Lang, Yang Xiang, Zhihua Ai, Zhiqing You, Xiaolan Jin, Yong Wan, Yongjian Yang
• Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology (Cell Physiol Biochem) Vol. 46 Issue 4 Pg. 1683-1692 ( 2018) ISSN: 1421-9778 [Electronic] Germany
• PMID: 29694982 (Publication Type: Journal Article)
• Copyright: © 2018 The Author(s). Published by S. Karger AG, Basel.

Chemical References

• Uncoupling Protein 3
• Sodium Chloride

Topics

• Animals
• Blood Pressure (drug effects)
• Cardiomegaly (etiology, metabolism)
• Echocardiography
• Energy Metabolism (drug effects)
• Heart (physiology)
• Male
• Mice
• Mice, Inbred C57BL
• Mice, Knockout
• Mitochondria (drug effects, metabolism)
• Myocardium (pathology)
• Sodium Chloride (pharmacokinetics)
• Uncoupling Protein 3 (deficiency, genetics)