Abstract |
Epicardium-derived cells (EPDCs) are an important pool of multipotent cardiovascular progenitor cells. Through epithelial-to-mesenchymal-transition (EMT), EPDCs invade the subepicardium and myocardium and further differentiate into several cell types required for coronary vessel formation. We previously showed that epicardial hypoxia inducible factor (HIF) signaling mediates the invasion of vascular precursor cells critical for patterning the coronary vasculature. Here, we examine the regulatory role of hypoxia (1% oxygen) on EPDC differentiation into vascular smooth muscle cells (VSMCs). RESULTS: CONCLUSION: Our results reveal a novel role of epicardial HIF in mediating coronary vasculogenesis by promoting their differentiation into VSMCs through noncanonical TGFβ signaling. These data elucidate that patterning of the coronary vasculature is influenced by epicardial hypoxic signals.
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Authors | Jiayi Tao, Joey V Barnett, Michiko Watanabe, Diana Ramírez-Bergeron |
Journal | Journal of cardiovascular development and disease
(J Cardiovasc Dev Dis)
Vol. 5
Issue 2
(Apr 13 2018)
ISSN: 2308-3425 [Electronic] Switzerland |
PMID | 29652803
(Publication Type: Journal Article)
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