Abstract | BACKGROUND: HYPOTHESIS: METHODS: A retrospective review of all patients with World Health Organization group 1 PAH evaluated between March 2001 and August 2008 was performed. Patients were stratified into groups based on serum albumin concentration ≤3.3 g/dL ( hypoalbuminemia) vs >3.3 g/dL. Clinical, hemodynamic, and survival comparisons were compared between groups using Student t test and χ2 test, followed by univariate analysis and multivariate logistic regression. RESULTS: A total of 163/273 (59.7%) patients had a documented serum albumin concentration. Hypoalbuminemia was present in 41 (25.2%) patients and serum albumin ≤3.3 g/dL represented the lowest quartile of serum albumin. Patients with hypoalbuminemia had higher rates of renal dysfunction (26.8% vs 9.8%, P =0.0069) and hepatic dysfunction (29.3% vs 6.6%, P <0.001), and lower hemoglobin levels (11.6 vs 13.4 g/dL, P < 0.001). Hemodynamic and functional capacity assessments were comparable between groups. Independent predictors of mortality included low albumin levels (hazard ratio [HR]: 0.485, P = 0.008), high right atrial systolic area (HR: 1.062, P = 0.003), low Fick-derived cardiac index (HR: 1.465, P = 0.016), and high New York Heart Association functional class (HR: 1.767, P = 0.042). Patients with hypoalbuminemia demonstrated a significantly lower survival rate at latest follow-up (P = 0.01). CONCLUSIONS: Lower serum albumin concentrations in patients with PAH are associated with higher mortality and can serve as a marker of disease severity in this patient population.
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Authors | David Snipelisky, Jacob Jentzer, Omar Batal, Zeina Dardari, Michael Mathier |
Journal | Clinical cardiology
(Clin Cardiol)
Vol. 41
Issue 6
Pg. 782-787
(Jun 2018)
ISSN: 1932-8737 [Electronic] United States |
PMID | 29604093
(Publication Type: Journal Article)
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Copyright | © 2018 Wiley Periodicals, Inc. |
Chemical References |
- ALB protein, human
- Biomarkers
- Serum Albumin, Human
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Topics |
- Adult
- Aged
- Biomarkers
(blood)
- Chi-Square Distribution
- Female
- Hemodynamics
- Humans
- Hypertension, Pulmonary
(blood, diagnosis, mortality, physiopathology)
- Hypoalbuminemia
(blood, diagnosis, mortality, physiopathology)
- Kaplan-Meier Estimate
- Logistic Models
- Male
- Middle Aged
- Multivariate Analysis
- Prognosis
- Proportional Hazards Models
- Retrospective Studies
- Risk Factors
- Serum Albumin, Human
(analysis)
- Severity of Illness Index
- Time Factors
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