Exosomal tetraspanins as regulators of cancer progression and metastasis and novel diagnostic markers.

Abstract

Exosomes are cell-cell communicators emerging as a new paradigm for noninvasive diagnosis and prognosis of treatment response. Exosomal tetraspanin proteins like CD63, CD9 and CD81 play a critical role in sorting, selective recruitment of biomolecules, target selection, cell-specific entry, capturing, angiogenesis and vasculogenesis. These tetraspanins are being used as markers for oral, colorectal and colon cancers and glioblastoma. However, exosomal markers with robust specificity for early detection of carcinomas are the furthest along. EXO CARTA database shows the presence of CD151 in exosomes of colorectal, melanoma, ovarian and prostate cancers. CD151 preferentially targets exosomes to lung, lymph node and stroma cells. The present review discussed the possible role of tetraspanins in the formation, cargo selection, target selection and uptake of exosomes and suggests exciting new directions for future research.

• Authors: Rama Rao Malla, Santhi Pandrangi, Seema Kumari, Murali Mohan Gavara, Anil Kumar Badana
• Journal: Asia-Pacific journal of clinical oncology (Asia Pac J Clin Oncol) Vol. 14 Issue 6 Pg. 383-391 (Dec 2018) ISSN: 1743-7563 [Electronic] Australia
• PMID: 29575602 (Publication Type: Journal Article, Review)
• Copyright: © 2018 John Wiley & Sons Australia, Ltd.

Chemical References

• Biomarkers, Tumor
• Tetraspanins

Topics

• Biomarkers, Tumor (metabolism)
• Disease Progression
• Exosomes (metabolism)
• Humans
• Neoplasm Metastasis
• Neoplasms (metabolism, pathology)
• Tetraspanins (metabolism)