Indoor black carbon of outdoor origin and oxidative stress biomarkers in patients with chronic obstructive pulmonary disease.

Abstract

OBJECTIVES:

We assessed relationships between indoor black carbon (BC) exposure and urinary oxidative stress biomarkers, 8-hydroxy-2'-deoxyguanosine (8-OHdG) and malondialdehyde (MDA), in participants with chronic obstructive pulmonary disease (COPD).

METHODS:

Eighty-two participants completed in-home air sampling for one week prior to providing urine samples up to four times in a year. Weekly indoor and daily outdoor concentrations were used to estimate indoor daily lags and moving averages. There were no reported in-home BC sources, thus indoor levels closely represented outdoor BC infiltration. Mixed effects regression models with a random intercept for each participant were used to assess relationships between indoor BC and 8-OHdG and MDA, adjusting for age, race, BMI, diabetes, heart disease, season, time of urine collection, urine creatinine, and outdoor humidity and temperature.

RESULTS:

There were positive effects of BC on 8-OHdG and MDA, with the greatest effect the day before urine collection (6.9% increase; 95% CI 0.9-13.3%, per interquartile range: 0.22 μg/m3) for 8-OHdG and 1 to 4 days before collection (8.3% increase; 95% CI 0.03-17.3% per IQR) for MDA. Results were similar in models adjusting for PM2.5 not associated with BC and NO2 (10.4% increase, 95% CI: 3.5-17.9 for 8-OHdG; 8.1% increase, 95% CI: -1.1-18.1 for MDA). Effects on 8-OHdG were greater in obese participants.

CONCLUSIONS:

We found positive associations between BC exposure and 8-OHdG and MDA, in which associations with 8-OHdG were stronger in obese participants. These results suggest that exposure to low levels of traffic-related pollution results in lipid peroxidation and oxidative DNA damage in individuals with COPD.

• Authors: Stephanie T Grady, Petros Koutrakis, Jaime E Hart, Brent A Coull, Joel Schwartz, Francine Laden, Junfeng Jim Zhang, Jicheng Gong, Marilyn L Moy, Eric Garshick
• Journal: Environment international (Environ Int) Vol. 115 Pg. 188-195 (06 2018) ISSN: 1873-6750 [Electronic] Netherlands
• PMID: 29574339 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.)
• Copyright: Published by Elsevier Ltd.

Chemical References

• Air Pollutants
• Biomarkers
• Soot

Topics

• Air Pollutants (analysis, toxicity)
• Biomarkers (analysis)
• Cohort Studies
• Humans
• Oxidative Stress (drug effects)
• Pulmonary Disease, Chronic Obstructive (epidemiology, physiopathology, urine)
• Soot (analysis, toxicity)