Abstract | OBJECTIVE: METHODS: We analyzed longitudinal changes in biochemical parameters obtained during health examinations before and after the diagnosis of SBMA. We estimated trajectories of clinical markers across years from the onset of weakness using linear mixed models and compared these trajectories with those estimated for male healthy controls and patients with amyotrophic lateral sclerosis (ALS) and Parkinson disease (PD). Moreover, we examined the relationship between serum creatinine level and the onset of symptoms using Kaplan-Meier curves. RESULTS: Between October 2014 and October 2017, we enrolled 40 patients with genetically confirmed SBMA, 48 healthy controls, 25 patients with ALS, and 20 patients with PD. In patients with SBMA, we evaluated the patients' data for a period of 17.3 ± 7.5 years, including 11.4 ± 7.1 years of preclinical phase. Decreases in serum creatinine occurred >10 years before the onset. The mean serum creatinine concentration was 0.56 mg/dL at the onset of weakness in patients with SBMA compared to 0.88 ± 0.10 mg/dL on final evaluation in healthy controls. Serum levels of alanine transaminase and aspartate transaminase showed tendencies to increase in preclinical SBMA. These preclinical changes of biomarkers were not observed in either ALS or PD. CONCLUSIONS:
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Authors | Yasuhiro Hijikata, Atsushi Hashizume, Shinichiro Yamada, Tomonori Inagaki, Daisuke Ito, Akihiro Hirakawa, Keisuke Suzuki, Naoki Atsuta, Takashi Tsuboi, Makoto Hattori, Akihiro Hori, Haruhiko Banno, Gen Sobue, Masahisa Katsuno |
Journal | Neurology
(Neurology)
Vol. 90
Issue 17
Pg. e1501-e1509
(04 24 2018)
ISSN: 1526-632X [Electronic] United States |
PMID | 29572281
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2018 American Academy of Neurology. |
Chemical References |
- Biomarkers
- Receptors, Androgen
- Creatinine
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Topics |
- Adult
- Aged
- Amyotrophic Lateral Sclerosis
(metabolism)
- Biomarkers
(blood, metabolism)
- Bulbo-Spinal Atrophy, X-Linked
(blood, genetics)
- Creatinine
(blood)
- Disease Progression
- Female
- Genetic Techniques
- Humans
- Kaplan-Meier Estimate
- Longitudinal Studies
- Male
- Middle Aged
- Parkinson Disease
(metabolism)
- Receptors, Androgen
(genetics)
- Retrospective Studies
- Trinucleotide Repeats
(genetics)
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