Abstract | BACKGROUND: The types of cells most significantly linked to individual subtypes of idiopathic interstitial pneumonias (IIPs) remain unclear. Few studies have examined CD163+ macrophages in IIPs. OBJECTIVE: We retrospectively aimed to immunohistochemically characterize the CD163+ macrophages in IIPs. METHODS: RESULTS: CD68+ macrophage density was significantly increased in the 3 subtypes of IIPs relative to that in the control group, although no difference was detected within the different IIPs. CD163+ macrophage density was significantly increased in NSIP and COP samples relative to that in IPF samples. The density ratio of CD163+ macrophages to CD68+ macrophages was significantly decreased in IPF/UIP samples relative to that in the others, while the densities in NSIP and COP were significantly higher than those in control cases. CONCLUSION: CD163+ macrophages show distinct profiles among IIPs, and the standardized numerical density is decreased in IPF cases that have poor prognoses.
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Authors | Masahiro Yamashita, Ryoko Saito, Shinji Yasuhira, Yuh Fukuda, Hironobu Sasamo, Tamotsu Sugai, Kohei Yamauchi, Makoto Maemondo |
Journal | Journal of immunology research
(J Immunol Res)
Vol. 2018
Pg. 1436236
( 2018)
ISSN: 2314-7156 [Electronic] Egypt |
PMID | 29507864
(Publication Type: Journal Article)
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Chemical References |
- Antigens, CD
- Antigens, Differentiation, Myelomonocytic
- CD163 antigen
- Receptors, Cell Surface
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Topics |
- Aged
- Antigens, CD
(metabolism)
- Antigens, Differentiation, Myelomonocytic
(metabolism)
- Case-Control Studies
- Cell Movement
- Cryptogenic Organizing Pneumonia
(diagnosis, immunology, pathology)
- Diagnosis, Differential
- Female
- Humans
- Idiopathic Interstitial Pneumonias
(diagnosis, immunology, pathology)
- Immunohistochemistry
- Lung
(metabolism, pathology)
- Macrophages
(immunology)
- Male
- Middle Aged
- Pulmonary Fibrosis
(immunology, pathology)
- Receptors, Cell Surface
(metabolism)
- Retrospective Studies
- Tomography, X-Ray Computed
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