Tissue inhibitor of the metalloproteinases-3 gene polymorphisms and carotid plaque susceptibility in the Han Chinese population.

Abstract

Tissue inhibitor of metalloproteinases (TIMPs) are endogenous inhibitors of matrix metalloproteinases that are involved in normal cellular processes and in the development and progression of atherosclerosis. Our purpose was to evaluate the polymorphisms of the TIMP-3 genes for their associations with carotid plaques or with serum protein levels in the Han Chinese population. Two promoter variants, -915A/G (rs2234921) and -1296T/C (rs9619311), were genotyped in 548 subjects with no plaques, 462 subjects with echogenic plaques, and 427 subjects with mixture plaques. The serum TIMP-3 levels were measured using an enzyme-linked immunosorbent assay (ELISA). There was a strong linkage disequilibrium between -1296T/C and -915A/G (D' = 1.0, r2 = 0.991). The individuals with the genotype (TC+CC) were 1.8 times more likely to have mixture plaques than the individuals with the TT genotype (P = 0.001, OR: 1.836, 95%CI: 1.269-2.665). The frequency of the C allele in the mixture plaque group was significantly higher than in the no plaque group (P = 0.009, CI: 1.119-2.187). We observed a significant elevation of the TIMP-3 levels in the serum of patients affected with mixture plaques compared to those with no plaques (P = 0.013). The current data suggest that genetic variation in the TIMP-3 genes may contribute to individual differences in mixture plaque susceptibility in the Han Chinese population.

• Authors: Zhou Zheng, Xinwei He, Min Zhu, Xiaoping Jin, Cai Li, Feng Zhu, Chenling Lv, Weiling Li, Xiaofei Hu, Wanfeng Wang, Feng Wang
• Journal: The International journal of neuroscience (Int J Neurosci) Vol. 128 Issue 10 Pg. 920-927 (Oct 2018) ISSN: 1563-5279 [Electronic] England
• PMID: 29498555 (Publication Type: Journal Article)

Chemical References

• TIMP3 protein, human
• Tissue Inhibitor of Metalloproteinase-3

Topics

• Adult
• Aged
• Aged, 80 and over
• Asian People (genetics)
• Carotid Stenosis (blood, genetics)
• China
• Female
• Genetic Predisposition to Disease
• Humans
• Linkage Disequilibrium
• Male
• Middle Aged
• Plaque, Atherosclerotic (blood, genetics)
• Polymorphism, Single Nucleotide
• Tissue Inhibitor of Metalloproteinase-3 (blood, genetics)