[Multidisciplinary Treatment for Squamous Cell Carcinoma of the Anal Canal].

Abstract

Chemoradiotherapy(CRT)has been recognized as a standard treatment for locoregional squamous cell carcinoma of the anal canal in Western countries. However, surgery had historically been considered as a standard treatment and there are only a few reports on CRT for anal canal cancer in Japan. In this study, we analyzed medical records of 5 anal canal cancer patients treated with CRT in our hospital between 2005 and 2015. Patients' characteristics were as follows: median age, 70 years (range 42-80 years); male/female, 1/4; and clinical Stage I / III a/ III b, 3/1/1. The regimens of chemotherapy were MMC plus 5-FU in 4 patients and CDDP in 1 patient. The median follow-up period was 30 months(range, 6 to 100 months). After CRT, 4 patients achieved complete response. The other patient with partial response underwent salvage surgery. All patients were alive without recurrence. In conclusion, our retrospective study showed that CRT is considered to be a standard treat- ment for anal canal cancer.

• Authors: Hideaki Karasawa, Shinobu Ohnuma, Kazuhiro Watanabe, Takahiro Tsuchiya, Hirofumi Imoto, Takeshi Aoki, Katsuyoshi Kudoh, Naoki Tanaka, Munenori Nagao, Tomoya Abe, Hiroaki Musha, Fuyuhiko Motoi, Takashi Kamei, Takeshi Naitoh, Michiaki Unno
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 44 Issue 12 Pg. 2009-2010 (Nov 2017) ISSN: 0385-0684 [Print] Japan
• PMID: 29394850 (Publication Type: Journal Article)

Topics

• Adult
• Aged
• Aged, 80 and over
• Anus Neoplasms (pathology, therapy)
• Carcinoma, Squamous Cell (therapy)
• Chemoradiotherapy
• Female
• Humans
• Male
• Middle Aged
• Prognosis