Fimasartan-induced liver injury in a patient with no adverse reactions on other types of angiotensin II receptor blockers: A case report.

Abstract

RATIONALE:

Angiotensin II receptor blockers (ARBs) are widely used for patients with hypertension, and fimasartan is a recently approved ARBs. Fimasartan can cause headache, dizziness, itching, and coughing. There have been several reports of hepatotoxicity in ARBs. However, there have not yet been published reports of the hepatotoxicity of fimasartan.

PATIENT CONCERNS:

A 73-year-old man with hypertension experienced liver injury after fimasartan administration. He had a previous history of taking 3 types of ARBs each for more than 2 years before taking fimasartan, and there were no side effects on ARBs except for fimasartan.

DIAGNOSES:

Other factors that could cause liver injury were excluded in diagnostic tests, and fimasartan was suspected to be the causative agent.

INTERVENTION:

Fimasartan was immediately discontinued and the patient was managed with supportive care via hepatotonics.

DIAGNOSES:

Other factors that could cause liver injury were excluded in diagnostic tests, and fimasartan was suspected to be the causative agent.

OUTCOME:

The liver injury due to fimasartan was confirmed by histology and accidental redosing.

LESSONS:

We emphasize that liver function should be monitored during fimasartan administration because fimasartan may cause hepatotoxicity in patients who have no side effects with other types of ARBs. And fimasartan-induced liver injury may appear later than other ARBs.

• Authors: Dae Hwa Park, Gee Young Yun, Hyuk Soo Eun, Jong Seok Joo, Ju Seok Kim, Sun Hyung Kang, Hee Seok Moon, Eaum Seok Lee, Byung Seok Lee, Kyung Hee Kim, Seok Hyun Kim
• Journal: Medicine (Medicine (Baltimore)) Vol. 96 Issue 47 Pg. e8905 (Nov 2017) ISSN: 1536-5964 [Electronic] United States
• PMID: 29382024 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2017 The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved.

Chemical References

• Angiotensin Receptor Antagonists
• Antihypertensive Agents
• Biphenyl Compounds
• Pyrimidines
• Tetrazoles
• fimasartan

Topics

• Aged
• Angiotensin Receptor Antagonists (adverse effects)
• Antihypertensive Agents (adverse effects)
• Biphenyl Compounds (adverse effects)
• Chemical and Drug Induced Liver Injury (etiology)
• Humans
• Hypertension (drug therapy)
• Male
• Pyrimidines (adverse effects)
• Tetrazoles (adverse effects)