Meaningful relief with flurbiprofen 8.75 mg spray in patients with sore throat due to upper respiratory tract infection.

Abstract

AIM:

Evaluate the efficacy of flurbiprofen 8.75 mg spray for sore throat relief.

PATIENTS & METHODS:

Randomized, double-blind study in adults with sore throat due to upper respiratory tract infection who took flurbiprofen (n = 249) or placebo spray (n = 256). Pain relief was assessed using the Sore Throat Relief Rating Scale.

RESULTS:

Flurbiprofen spray provided significantly greater relief versus placebo from 20 min to 6 h (p < 0.0001; maximum difference: 75 min). Sore throat severity was reduced ≥-2.2 on the Sore Throat Scale from 75 min to 6 h, indicating meaningful relief. Significantly more patients taking flurbiprofen spray reported ≥30 min of 'at least moderate' relief versus placebo over 6 h (p < 0.0001). Most adverse events were mild.

CONCLUSION:

Flurbiprofen spray provides rapid, long-lasting and clinically meaningful relief from sore throat (ANZCTR: ACTRN12612000457842).

• Authors: Ferdinandus de Looze, Marc Russo, Mark Bloch, Barney Montgomery, Adrian Shephard, Robert DeVito
• Journal: Pain management (Pain Manag) Vol. 8 Issue 2 Pg. 79-83 (Mar 2018) ISSN: 1758-1877 [Electronic] England
• PMID: 29376761 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Flurbiprofen

Topics

• Administration, Oral
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Double-Blind Method
• Flurbiprofen (therapeutic use)
• Humans
• Pharyngitis (drug therapy, etiology)
• Respiratory Tract Infections (complications)
• Severity of Illness Index
• Treatment Outcome