Changes in the 32P incorporation in rat mammary tumor after chronic administration of LH-RH analogs.

Abstract

We studied endogenous phosphorylation in rat transplantable MT/W9A hormone-dependent mammary tumors of untreated rats and of animals treated with LH-RH analogs, the agonist D-Trp-6-LH-RH and the antagonist N-Ac-D-p-Cl-Phe1,2,D-Trp3,D-Arg6,D-Ala10-LH-RH. Incorporation of 32P from 32P-ATP was reduced significantly in tumors of rats treated with agonistic and antagonistic analogs of LH-RH or ovariectomized. The inhibition of protein phosphorylation may be related to tumor regression.

• Authors: G Cehovic, T W Redding, A V Schally
• Journal: Medical oncology and tumor pharmacotherapy (Med Oncol Tumor Pharmacother) Vol. 2 Issue 4 Pg. 243-7 ( 1985) ISSN: 0736-0118 [Print] England
• PMID: 2935686 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Neoplasm Proteins
• Phosphorus Radioisotopes
• Triptorelin Pamoate
• Gonadotropin-Releasing Hormone
• LHRH, N-acetyl-(4-chlorophenylalanyl)(1)-(4-chlorophenylalanyl)(2)-tryptophyl(3)-arginyl(6)-alanine(10)-

Topics

• Animals
• Autoradiography
• Female
• Gonadotropin-Releasing Hormone (analogs & derivatives, pharmacology)
• Mammary Neoplasms, Experimental (metabolism)
• Neoplasm Proteins (metabolism)
• Neoplasms, Hormone-Dependent (metabolism)
• Ovariectomy
• Phosphorus Radioisotopes
• Phosphorylation
• Rats
• Rats, Inbred WF
• Triptorelin Pamoate