Abstract | BACKGROUND:
Breast cancer is an alarming global public health problem and a main cause of cancer-related death in women. Systemic chemotherapy is the most widely used treatment for breast cancer. However, current chemotherapy treatments are far from desirable due to poor targeting specificity, severe side effects and vasculogenic mimicry (VM). PURPOSE: METHODS: HA-modified daunorubicin plus HNK cationic liposomes were prepared by a thin-film hydration method. Evaluations were performed on MCF-7 cells and MDA-MB-435S cells, which are human breast cancer cells, and xenografts of MDA-MB-435S cells. RESULTS: In vitro results revealed that the HA-modified daunorubicin plus HNK cationic liposomes enhanced the cellular uptake and destroyed VM channels. In vivo results demonstrated that the liposomes prolonged the circulation time in the blood, obviously accumulated in the tumour region, and enhanced the overall anticancer effects. Action mechanisms were related to down-regulation of VM protein indicators including FAK, EphA2, MMP-2 and MMP-9. CONCLUSIONS:
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Authors | Rui-Jun Ju, Lan Cheng, Xiao Qiu, Shuang Liu, Xiao-Li Song, Xiao-Ming Peng, Teng Wang, Cui-Qing Li, Xue-Tao Li |
Journal | Journal of drug targeting
(J Drug Target)
Vol. 26
Issue 9
Pg. 793-805
(11 2018)
ISSN: 1029-2330 [Electronic] England |
PMID | 29334266
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biphenyl Compounds
- Cations
- Lignans
- Liposomes
- honokiol
- Hyaluronic Acid
- Daunorubicin
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Topics |
- Animals
- Biphenyl Compounds
(chemistry)
- Breast Neoplasms
(drug therapy, pathology)
- Cations
- Daunorubicin
(chemistry, therapeutic use)
- Female
- Humans
- Hyaluronic Acid
(chemistry)
- Lignans
(chemistry)
- Liposomes
- MCF-7 Cells
- Mice
- Neovascularization, Pathologic
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