Cerebellar metastasis of papillary thyroid carcinoma detected with somatostatin receptor scintigraphy.

Abstract

INTRODUCTION:

Distant metastases of papillary thyroid carcinoma (PTC) may lack the ability to concentrate radioiodine. In such cases, positive somatostatin receptor scintigraphy might be useful in demonstrating the expression of somatostatin receptors that are potential therapeutic targets. To date, only a few cerebellar metastases from PTC have been reported in the literature.

PATIENT FINDINGS:

We present an 82-year-old female, in whom an asymptomatic cerebellar metastasis from PTC was diagnosed by means of Tc-99m-EDDA/HYNIC-TOC scintigraphy four years after the initial diagnosis. She was previously treated with total thyroidectomy and regional lymph node dissection, followed by three cycles of radioiodine therapy. Despite persistently elevated thyroglobulin, no specific radioiodine accumulation was found in the whole body post-treatment scan. Tc-99m-EDDA/HYNIC-TOC scintiscan revealed foci of increased tracer uptake in the lungs, cervical lymph nodes, and a single focus in the head. Thus, therapy with octreotide LAR was initiated. The patient died four months later due to disseminated PTC.

SUMMARY:

In this paper, a patient with asymptomatic previously unknown non-iodine avid cerebellar metastasis of PTC diagnosed by means of scintigraphy using somatostatin analogue Tc-99m-EDDA/HYNIC-TOC is reported.

CONCLUSIONS:

Somatostatin receptor scintigraphy might be useful in the visualisation of non-iodine avid PTC metastases and demonstrat-ing the expression of somatostatin receptors that are potential therapeutic targets.

• Authors: Rafał Czepczyński, Anna Wyszomirska, Maria Gryczyńska, Ewelina Szczepanek-Parulska, Marek Ruchała
• Journal: Endokrynologia Polska (Endokrynol Pol) Vol. 69 Issue 1 Pg. 24-27 ( 2018) ISSN: 2299-8306 [Electronic] Poland
• PMID: 29319129 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents, Hormonal
• Receptors, Somatostatin
• EDDA
• Technetium
• Edetic Acid
• Octreotide

Topics

• Aged, 80 and over
• Antineoplastic Agents, Hormonal (therapeutic use)
• Carcinoma, Papillary (diagnostic imaging, metabolism, secondary)
• Cerebellar Neoplasms (diagnostic imaging, metabolism, secondary)
• Edetic Acid (analogs & derivatives)
• Gene Expression Regulation, Neoplastic
• Humans
• Male
• Octreotide (therapeutic use)
• Radionuclide Imaging
• Receptors, Somatostatin (analysis, genetics)
• Technetium
• Thyroid Cancer, Papillary
• Thyroid Neoplasms (diagnostic imaging, metabolism, pathology, secondary)