Abstract | BACKGROUND: Although there are many clinical studies in which the beneficial effect of glutamine formulation on mucositis induced by chemo/ radiotherapy was evaluated, the results are sometimes conflicting with the report of clinical deterioration. Then, we hypothesized that chemotherapy may increase the incidence of hyperammonemia without comparable change of major parameters of hepatic/renal disorder. METHODS: RESULTS: CONCLUSION: These results indicates that CDDP enhances the increase in blood ammonia level by glutamine supplementation without correlating with primary parameters for hepatic/renal dysfunction.
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Authors | Yoko Obayashi, Kenta Kajiwara, Eiji Nakamura |
Journal | Pharmacology
(Pharmacology)
Vol. 101
Issue 3-4
Pg. 156-162
( 2018)
ISSN: 1423-0313 [Electronic] Switzerland |
PMID | 29301138
(Publication Type: Journal Article)
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Copyright | © 2018 S. Karger AG, Basel. |
Chemical References |
- Antineoplastic Agents
- Dipeptides
- Glutamine
- Glutamic Acid
- Ammonia
- Creatinine
- Aspartate Aminotransferases
- Alanine Transaminase
- Cisplatin
- alanylglutamine
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Topics |
- Alanine Transaminase
(blood)
- Ammonia
(blood)
- Animals
- Antineoplastic Agents
(adverse effects)
- Aspartate Aminotransferases
(blood)
- Blood Urea Nitrogen
- Cisplatin
(adverse effects)
- Creatinine
(blood)
- Dipeptides
(pharmacology)
- Glutamic Acid
(blood)
- Glutamine
(blood)
- Intestinal Mucosa
(drug effects, pathology)
- Male
- Rats
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