Abstract | OBJECTIVE: DESIGN: We performed blinded analysis of the electrolyte concentration of albumin samples obtained directly from the national blood supplier (Canadian Blood Services). Two-tailed independent t tests were performed for all possible comparative analyses. Analysis of variance testing was performed for relevant three-way comparisons. Significance threshold was set at p less than 0.05. SETTING: All samples were analyzed in the core laboratory at an academic hospital associated with McMaster University in Hamilton, Ontario, Canada. SUBJECTS: We analyzed 65 albumin samples from three available brands obtained through Canadian Blood Services. They include Plasbumin (n = 21), Alburex (n = 24), Octalbin (n = 20). INTERVENTION: Laboratory technologists blinded to product identification measured the concentration of electrolytes, extended electrolytes, lactate, and albumin of each sample using the Abbott ARCHITECT c8000 chemistry analyzer. MEASUREMENTS AND MAIN RESULTS: The mean chloride concentration of Plasbumin, Alburex, and Octalbin, respectively, were 109.4 mmol/L (SD, 1.3), 123.6 mmol/L (SD, 1.3), and 136.8 mmol/L (SD, 0.4). The mean sodium concentration of Plasbumin, Alburex, and Octalbin, respectively, were 139.6 mmol/L (SD, 1.6), 137.3 mmol/L (SD, 2.2), and 149.4 mmol/L (SD, 0.5). The chloride and sodium concentration differed significantly for all two-way comparisons (p < 0.0001) and multiple comparison testing (p < 0.0001). CONCLUSION: This study is the first to identify and document a statistically significant variability in the chloride concentration of available 5% albumin products. This study has also informed a pilot randomized controlled trial examining the effect of administering high chloride versus low chloride fluids in critically ill patients with sepsis.
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Authors | Alison T Lai, Michelle P Zeller, Tina Millen, Peter Kavsak, Wojciech Szczeklik, Allahna Elahie, Waleed Alhazzani, Frederick D'Aragon, Roman Jaeschke, Francois Lamontagne, Timothy Karachi, Deborah Cook, Maureen Meade, Bram Rochwerg, Canadian Critical Care Trials Group |
Journal | Critical care medicine
(Crit Care Med)
Vol. 46
Issue 4
Pg. e326-e329
(04 2018)
ISSN: 1530-0293 [Electronic] United States |
PMID | 29293151
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Albumins
- Electrolytes
- Chlorine
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Topics |
- Albumins
(administration & dosage, chemistry)
- Chlorine
(chemistry)
- Electrolytes
(chemistry)
- Fluid Therapy
(methods)
- Humans
- Single-Blind Method
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