Long-Term Topical Diquafosol Tetrasodium Treatment of Dry Eye Disease Caused by Chronic Graft-Versus-Host Disease: A Retrospective Study.

Abstract

OBJECTIVES:

The aim of this study was to assess the safety and efficacy of long-term use of 3% diquafosol ophthalmic solution (DQS), an eye drop for mucin production and water secretion, for treating dry eye disease (DED) caused by chronic graft-versus-host disease (cGVHD).

METHODS:

We retrospectively evaluated the safety and efficacy of DQS in 10 patients with mild to moderate cGVHD-induced DED. The efficacy was assessed by (1) degree of symptoms, (2) Schirmer I test value, (3) tear film breakup time (TFBUT), and (4) fluorescein and rose bengal scores.

RESULTS:

The median duration of DQS treatment was 12.0 months (range 6-17 months). DQS was effective for relieving severe pain caused by cGVHD-related DED. Although the Schirmer I test value was enhanced only marginally, the long-term application of DQS significantly improved the corneal/conjunctival epitheliopathy and tear film stability: the fluorescein score improved from 5.9±0.6 to 1.3±1.1 points (P=1.771×10); rose bengal staining from 4.7±1.6 to 2.0±1.5 points (P=0.008); and TFBUT from 2.6±0.9 to 4.6±1.6 mm (P=0.009). Furthermore, the long-term DQS treatment caused no major adverse events.

CONCLUSIONS:

This study suggested that long-term DQS treatment is a safe and robust approach for alleviating cGVHD-related DED.

• Authors: Mio Yamane, Yoko Ogawa, Masaki Fukui, Mizuka Kamoi, Miki Uchino, Yumiko Saijo-Ban, Naoyuki Kozuki, Shin Mukai, Takehiko Mori, Shinichiro Okamoto, Kazuo Tsubota
• Journal: Eye & contact lens (Eye Contact Lens) Vol. 44 Suppl 2 Pg. S215-S220 (Nov 2018) ISSN: 1542-233X [Electronic] United States
• PMID: 29280750 (Publication Type: Journal Article)

Chemical References

• Mucins
• Ophthalmic Solutions
• Polyphosphates
• Uracil Nucleotides
• diquafosol

Topics

• Adult
• Aged
• Conjunctiva (metabolism)
• Cornea (metabolism, pathology)
• Dry Eye Syndromes (drug therapy, etiology, physiopathology)
• Female
• Graft vs Host Disease (complications)
• Humans
• Male
• Middle Aged
• Mucins (metabolism)
• Ophthalmic Solutions (administration & dosage)
• Polyphosphates (administration & dosage)
• Retrospective Studies
• Tears (metabolism)
• Uracil Nucleotides (administration & dosage)