Hepatic Resection Followed by Hepatic Arterial Infusion Chemotherapy for Hepatocellular Carcinoma with Intrahepatic Dissemination.

Abstract

BACKGROUND/AIM:

To investigate the utility of adjuvant hepatic arterial infusion chemotherapy (HAIC) following hepatectomy for patients with hepatocellular carcinoma (HCC) with intrahepatic dissemination (IHD) after local ablation therapy.

PATIENTS AND METHODS:

Twelve patients with HCC with IHD were divided into two groups: HAIC group (n=6) underwent hepatectomy followed by HAIC; and the non-HAIC group (n=6) underwent hepatectomy alone. HAIC with cisplatin and 5-fluorouracil was started within a month and was continued for a month: Results: At the first local ablation, tumors close to the major portal vein and insufficient ablation were recognized in eight (67.7%) and six (58.3%) of the patients, respectively. In the HAIC group, the 1-, 3-, and 5-year disease-free and overall survival rates were 50.0%, 16.7%, and 16.7%, and 83.3%, 83.3% and 62.5%, respectively. Three patients in the HAIC group remain alive after 10 years of follow-up.

CONCLUSION:

Hepatic resection with short-term postoperative HAIC may provide excellent outcomes in patients with HCC and IHD.

• Authors: Kunitaka Kuramoto, Toru Beppu, Hidetoshi Nitta, Katsunori Imai, Toshiro Masuda, Tatsunori Miyata, Yuki Koga, Yuki Kitano, Takayoshi Kaida, Shigeki Nakagawa, Hirohisa Okabe, Hiromitsu Hayashi, Daisuke Hashimoto, Yo-Ichi Yamashita, Akira Chikamoto, Ken Kikuchi, Hideo Baba
• Journal: Anticancer research (Anticancer Res) Vol. 38 Issue 1 Pg. 525-531 (01 2018) ISSN: 1791-7530 [Electronic] Greece
• PMID: 29277819 (Publication Type: Journal Article)
• Copyright: Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Chemical References

• Antimetabolites, Antineoplastic
• Cisplatin
• Fluorouracil

Topics

• Aged
• Antimetabolites, Antineoplastic (therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Carcinoma, Hepatocellular (drug therapy, pathology, surgery)
• Cisplatin (therapeutic use)
• Combined Modality Therapy (methods)
• Disease-Free Survival
• Female
• Fluorouracil (therapeutic use)
• Hepatectomy (methods)
• Hepatic Artery
• Humans
• Infusions, Intra-Arterial
• Liver (pathology)
• Liver Neoplasms (drug therapy, pathology, surgery)
• Male
• Middle Aged