Abstract | BACKGROUND: CASE PRESENTATION: A 61-year-old woman had a right adrenal grand tumor and lymph node metastasis on the hilum of the right kidney, both of which incorporated MIBG. After surgery, immunostaining of a tumor specimen showed expression of the tumor makers chromogranin and synaptophysin. One year postoperatively, abdominal computed tomography revealed a local recurrence and retroperitoneal lymph node swelling. The local recurrence was positive for MIBG uptake, whereas the swollen retroperitoneal lymph nodes were negative. She underwent surgery again, but the local recurrence was unresectable because of rigid adhesion to the surrounding tissue. Immunostaining of an intraoperatively extracted swollen retroperitoneal lymph node showed expression of tumor markers. The patient then underwent a single session of 131I-MIBG therapy (7.4 GBq, 200 mCi), after which the residual lesions no longer incorporated MIBG, and a complete response in 123I- metaiodobenzylguanidine ( MIBG) scintigraphy was achieved. The 131I-MIBG treatment was repeated 6 months later. None of the lesions were positive for MIBG uptake. CONCLUSIONS: 131I-MIBG therapy efficaciously treats unresectable lesions that are positive for MIBG uptake.
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Authors | Teruaki Sugino, Ryosuke Ando, Rei Unno, Keitaro Iida, Taku Naiki, Shuzo Hamamoto, Kentaro Mizuno, Atsushi Okada, Yukihiro Umemoto, Noriyasu Kawai, Keiichi Tozawa, Yutaro Hayashi, Anri Inaki, Daiki Kayano, Seigo Kinuya, Takahiro Yasui |
Journal | BMC research notes
(BMC Res Notes)
Vol. 10
Issue 1
Pg. 750
(Dec 19 2017)
ISSN: 1756-0500 [Electronic] England |
PMID | 29258609
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Iodine Radioisotopes
- 3-Iodobenzylguanidine
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Topics |
- 3-Iodobenzylguanidine
(pharmacokinetics)
- Adrenal Gland Neoplasms
(diagnostic imaging, radiotherapy, surgery)
- Female
- Humans
- Iodine Radioisotopes
(pharmacokinetics, therapeutic use)
- Middle Aged
- Pheochromocytoma
(diagnostic imaging, radiotherapy, surgery)
- Radionuclide Imaging
(methods)
- Remission Induction
- Tomography, X-Ray Computed
(methods)
- Treatment Outcome
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