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3-Iodobenzylguanidine (Iobenguane)

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A guanidine analog with specific affinity for tissues of the sympathetic nervous system and related tumors. The radiolabeled forms are used as antineoplastic agents and radioactive imaging agents. (Merck Index, 12th ed) MIBG serves as a neuron-blocking agent which has a strong affinity for, and retention in, the adrenal medulla and also inhibits ADP-ribosyltransferase.

Also Known As:

Iobenguane; MIBG; 3-Iodobenzylguanidine, 123I Labeled; 3-Iodobenzylguanidine, 125I Labeled; Iobenguane (131I); m-Iodobenzylguanidine; meta-Iodobenzylguanidine; 123I Labeled 3-Iodobenzylguanidine; 125I Labeled 3-Iodobenzylguanidine; 3 Iodobenzylguanidine; 3 Iodobenzylguanidine, 123I Labeled; 3 Iodobenzylguanidine, 125I Labeled; m Iodobenzylguanidine; meta Iodobenzylguanidine; (3-Iodo-(131I)benzyl)guanidine

Networked: 1648 relevant articles (108 outcomes, 274 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Matthay, Katherine K: 24 articles (06/2015 - 07/2003)
2.	Orimo, Satoshi: 16 articles (09/2015 - 01/2003)
3.	Jacobson, Arnold F: 14 articles (07/2015 - 03/2008)
4.	Zhuang, Hongming: 12 articles (06/2015 - 11/2006)
5.	Maris, John M: 12 articles (06/2014 - 10/2003)
6.	Yamashina, Shohei: 10 articles (07/2013 - 12/2003)
7.	Pacak, Karel: 10 articles (05/2012 - 09/2003)
8.	Uchihara, Toshiki: 9 articles (09/2015 - 11/2004)
9.	Boyd, Marie: 9 articles (09/2011 - 02/2005)
10.	Agostini, Denis: 8 articles (11/2015 - 03/2008)

Related Diseases

1.	Neuroblastoma 03/01/1997 - "This suggests that the positive effects observed by the treatment of neuroblastoma patients with the combination of HBO and [131I] MIBG are most likely not due to improved uptake or retention of MIBG in the neuroblastoma. " 11/01/1993 - "Metaiodobenzylguanidine (MIBG) is highly effective in the detection of neuroblastoma. " 07/01/1993 - "(4) Iodine-125 MIBG therapy in neuroblastoma: Is the improved energy deposition of 125I at extremely short range useful in the ablation of micrometastases? " 07/01/1985 - "Iodine-131 MIBG scintigraphy was more effective in demonstrating the extent of neuroblastoma spread than were conventional bone scan and CT in one patient, equal to these modalities in four cases, almost equal in two cases and significantly inferior in three cases. " 07/01/1993 - "Current controversies in the application of MIBG include (1)131I versus 123I as a label for imaging studies: Although improved image quality and reduced absorbed radiation dose are achieved with [123I]MIBG imaging, is it actually more efficacious in the detection of neuroblastoma? "
2.	Pheochromocytoma 09/01/2013 - "I-MIBG hybrid SPECT-CT shows high sensitivity and specificity for characterizing adrenal lesions in patients with clinical or biochemical suspicion of pheochromocytoma and is superior to PS and SPECT alone. " 10/01/2005 - "Promising results have been published on single high-dosage [131I]metaiodobenzylguanidine ([131I]MIBG) treatment for malignant pheochromocytoma. " 07/01/1999 - "After surgical removal of the pheochromocytoma, cardiac MIBG uptake and the heart:mediastinum uptake ratios improved significantly (197% +/- 20%, P < 0.05) in all the patients. " 04/01/1985 - "Rapid clearance of iodine-131 MIBG from the heart and liver of patients with adrenergic dysfunction and pheochromocytoma." 04/01/2007 - "[(18)F]DA PET was found to show more promising results when compared with [(123/131)I]MIBG scintigraphy in the diagnostic localization of VHL-related adrenal pheochromocytoma, with a 100% rate of localization. "
3.	Neoplasms (Cancer) 01/01/1987 - "MIBG therapy was most effective in patients with slower-growing tumors for whom initial treatment doses were 200 mCi or more." 08/01/1987 - "She received two therapy doses of I-131 MIBG (35 mCi and 75 mCi) with curative intention giving a total absorbed dose in the tumor of approximately 76 Gy. In spite of high retention of radioactivity in the tumor, regression did not occur, but her general condition was improved. " 06/01/1995 - "The accumulation of no-carrier-added [131I]MIBG was significantly greater in tumor, adrenal, heart and skin of tumor-bearing mice than that of the conventional therapy preparation of [131I]MIBG. " 08/01/2012 - "Five patients had partial responses; 9 others had a 23%-60% decrease in primary tumor volume and/or improved MIBG scans or decreased bone or bone marrow tumor burden. " 04/01/2011 - "Radiolabelled with I-123 or I-131, mIBG has become a gold standard for diagnostic imaging of pediatric and adult neuroendocrine cancer. "
4.	Heart Failure 10/01/2012 - "Selective improvement in Seattle Heart Failure Model risk stratification using iodine-123 meta-iodobenzylguanidine imaging." 01/01/2001 - "The MIBG tarot: is it possible to predict the efficacy of beta-blockers in congestive heart failure?" 04/01/1995 - "[Serial assessment of MIBG scintigraphy in a case of DCM with heart failure improved by beta-blocker therapy]." 11/01/2015 - "The ADRECARD study demonstrated that determination of late HMR during cardiac MIBG imaging using dual isotope ((123)I and (99m)Tc) acquisition on a CZT camera (D-SPECT) is feasible in patients with heart failure. " 11/01/2015 - "First determination of the heart-to-mediastinum ratio using cardiac dual isotope (¹²³I-MIBG/⁹⁹mTc-tetrofosmin) CZT imaging in patients with heart failure: the ADRECARD study."
5.	Paraganglioma (Paragangliomas) 08/01/2006 - "Stable disease and improved health-related quality of life (HRQoL) following fractionated low dose 131I-metaiodobenzylguanidine (MIBG) therapy in metastatic paediatric paraganglioma: observation on false "reverse" discordance during pre-therapy work up and its implication for patient selection for high dose targeted therapy." 09/01/1994 - "MRI is as effective as MIBG scintigraphy in detecting functioning paragangliomas. " 05/01/1999 - "In this study, the influence of clinical features and tumour pathology on the results of 131I MIBG of patients with phaeochromocytomas and paragangliomas was examined. " 12/01/1996 - "We compared iodine-131 metaiodobenzylguanidine (MIBG), computed tomography (CT) and magnetic resonance (MR) imaging studies in 40 patients with suspected or proven paragangliomas. " 12/01/2015 - "MIBG uptake in malignant paragangliomas was lower than in malignant phaeochromocytomas (36% vs. 100%, P = 0.002) and disease stabilisation was achieved in 29% and 86% of patients respectively. "

Related Drugs and Biologics

1.	3-Iodobenzylguanidine (Iobenguane)
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3.	N-acetyltalosaminuronic acid (NAT)
4.	Iodine
5.	Guanidine (Guanidine Nitrate)
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7.	pentetreotide (OctreoScan)
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