Plasma MicroRNA-21, 26a, and 29a-3p as Predictive Markers for Treatment Response Following Transarterial Chemoembolization in Patients with Hepatocellular Carcinoma.

Abstract

BACKGROUND:

We investigated an association between the levels of plasma microRNA (miRNA)-21, -26a, and -29a-3p and treatment outcomes following transarterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC).

METHODS:

A total of 198 patients with TACE-treated HCC were followed up for TACE refractoriness and liver transplantation (LT)-free survival. Pretreatment plasma miRNA-21, -26a, and -29a-3p levels were measured using quantitative real-time polymerase chain reaction.

RESULTS:

During the mean follow-up of 22.3 (range, 0.7-79) months, 118 (59.6%) patients exhibited TACE refractoriness. Multivariate analyses showed that expression of a specific combination of miRNAs (miRNA-21 ≥ 2.5, miRNA-26a ≥ 1.5, and miRNA-29a-3p < 0.4) was associated with early TACE refractoriness (within 1 year; hazard ratio [HR], 2.32; 95% confidence interval [CI], 1.08-4.99; P = 0.031) together with tumor size (HR, 4.62; 95% CI, 1.50-14.21; P = 0.008), and macrovascular invasion (HR, 3.80; 95% CI, 1.19-12.20; P = 0.025). However, miRNA-21, -26a, and -29a-3p levels were not significantly associated with overall TACE refractoriness or LT-free survival. Additionally, large tumor size and macrovascular invasion were common predictive factor of overall TACE refractoriness and survival.

CONCLUSION:

Combination of plasma miRNA-21, -26a, and -29a-3p expression could predict early TACE refractoriness in patients with TACE-treated HCC.

• Authors: Soon Sun Kim, Hyo Jung Cho, Ji Sun Nam, Hyun Ji Kim, Dae Ryong Kang, Je Hwan Won, Jinoo Kim, Jai Keun Kim, Jei Hee Lee, Bo Hyun Kim, Mi Young Lee, Sung Won Cho, Jae Youn Cheong
• Journal: Journal of Korean medical science (J Korean Med Sci) Vol. 33 Issue 1 Pg. e6 (Jan 01 2018) ISSN: 1598-6357 [Electronic] Korea (South)
• PMID: 29215815 (Publication Type: Journal Article)
• Copyright: © 2018 The Korean Academy of Medical Sciences.

Chemical References

• MIRN21 microRNA, human
• MIRN26A microRNA, human
• MIRN29a microRNA, human
• MicroRNAs
• Doxorubicin

Topics

• Aged
• Area Under Curve
• Carcinoma, Hepatocellular (mortality, pathology, therapy)
• Chemoembolization, Therapeutic
• Doxorubicin (administration & dosage)
• Female
• Humans
• Liver Neoplasms (mortality, pathology, therapy)
• Male
• MicroRNAs (blood)
• Middle Aged
• Neoplasm Staging
• Proportional Hazards Models
• ROC Curve
• Real-Time Polymerase Chain Reaction
• Survival Rate