Abstract | BACKGROUND: METHODS: One hundred patients who underwent coronary angiography were enrolled. The plasma LPL, HTGL and GPIHBP1 concentrations were determined by ELISA. The time dependent changes in those lipases, lipids and lipoproteins were studied at a time-point just before, and 15min, 4h and 24h after heparin administration. RESULTS: The LPL concentration exhibited a significant positive correlation with HDL-C, and inversely correlated with TG and RLP-C. The HTGL concentration was positively correlated with RLP-C and sdLDL-C. The HTGL ratio of the pre- heparin/post- heparin plasma concentration and sdLDL-C/ LDL-C ratio were significantly greater in CAD patients than in non-CAD patients. GPIHBP1 was positively correlated with LPL and inversely correlated with RLP-C and sdLDL-C. CONCLUSION: The HTGL concentration was positively correlated with RLP-C and sdLDL-C, while LPL and GPIHBP1 were inversely correlated with RLP-C and sdLDL-C. These results suggest that elevated HTGL is associated with increased CAD risk, while elevated LPL is associated with a reduction of CAD risk.
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Authors | Yuji Muraba, Takafumi Koga, Yohnosuke Shimomura, Yasuki Ito, Yuko Hirao, Junji Kobayashi, Takao Kimura, Katsuyuki Nakajima, Masami Murakami |
Journal | Clinica chimica acta; international journal of clinical chemistry
(Clin Chim Acta)
Vol. 476
Pg. 146-153
(Jan 2018)
ISSN: 1873-3492 [Electronic] Netherlands |
PMID | 29174344
(Publication Type: Journal Article)
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Copyright | Copyright © 2017. Published by Elsevier B.V. |
Chemical References |
- Cholesterol, LDL
- GPIHBP1 protein, human
- Lipoproteins
- Receptors, Lipoprotein
- Lipase
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Topics |
- Aged
- Cholesterol, LDL
(blood, metabolism)
- Coronary Artery Disease
(blood, diagnosis, metabolism)
- Female
- Humans
- Lipase
(blood, metabolism)
- Lipoproteins
(blood, metabolism)
- Liver
(enzymology, metabolism)
- Male
- Middle Aged
- Receptors, Lipoprotein
(blood, metabolism)
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