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Introduction: How We Encountered TCTP and Our Purpose in Studying It.

Abstract
In this brief introduction, we describe our encounter with TCTP. Back in 2000, we discovered TCTP in two quite different ways: first, we looked at protein partners of TSAP6 and one of them was TCTP. Then, in collaboration with Sidney Brenner, we performed a high-throughput differential screening comparing the parental cancer cells with revertants. The results indicated that TCTP was of the most differentially expressed genes. These two approaches were carried out only months apart. They guided our research and led to the discoveries of drugs that inhibit the function of TCTP. Much of the preclinical data on sertraline as an inhibitor of TCTP in cancer were obtained with Judith Karp at Johns Hopkins. This drug is now given in combination with Ara-C to patients in a phase I clinical trial for Acute Myeloid Leukemia. We will here detail how all this happened in our lab while working around one central project: tumor reversion.
AuthorsAdam Telerman, Robert Amson
JournalResults and problems in cell differentiation (Results Probl Cell Differ) 2017 Vol. 64 Pg. 1-8 ISSN: 0080-1844 [Print] Germany
PMID29149401 (Publication Type: Historical Article, Journal Article)
Chemical References
  • Biomarkers, Tumor
  • Cell Cycle Proteins
  • Oncogene Proteins
  • TPT1 protein, human
  • Tumor Protein, Translationally-Controlled 1
  • Cytarabine
  • Oxidoreductases
  • STEAP3 protein, human
  • Sertraline
Topics
  • Biomarkers, Tumor (antagonists & inhibitors, genetics, history, metabolism)
  • Cell Cycle Proteins
  • Clinical Trials, Phase I as Topic
  • Cytarabine (administration & dosage, therapeutic use)
  • Gene Expression Regulation, Neoplastic
  • History, 21st Century
  • Humans
  • Leukemia, Myeloid, Acute (drug therapy, metabolism)
  • Neoplasms (drug therapy, genetics, metabolism, pathology)
  • Oncogene Proteins (antagonists & inhibitors, genetics, metabolism)
  • Oxidoreductases
  • Sertraline (administration & dosage, pharmacology, therapeutic use)
  • Tumor Protein, Translationally-Controlled 1

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