Abstract | BACKGROUND: OBJECTIVE: The aim of this study was to update previous analyses using the North American Contact Dermatitis Group data comparing pierced and unpierced individuals. METHODS: This was a retrospective cross-sectional analysis of 17,912 patients patch tested by the North American Contact Dermatitis Group from 2007 to 2014 for demographics, positive reactions to metals ( nickel, cobalt, chromium), and detailed analysis of nickel reactions by age, sex, and source of exposure. RESULTS: Piercing was significantly associated with female sex, being older than 18 years, and atopy (P < 0.003). Nickel sensitivity was associated with 1 or more piercing for men and women combined (P < 0.0001; relative risk [RR], 2.54; 95% confidence interval [CI], 2.35-2.75), although this association was stronger for men (RR, 2.21; 95% CI, 1.77-2.76) than women (RR, 1.47; 95% CI, 1.31-1.65). The frequency of positivity to nickel increased with number of piercings (14.3% for 1 piercing to 34.0% with ≥5 piercings). Piercing was not significantly associated with cobalt sensitivity alone (P = 0.8992) and was negatively associated with chromium sensitivity (P < 0.0001). Jewelry was the most common source of allergic reactions to nickel irrespective of sex or pierced status. CONCLUSIONS:
Nickel sensitivity was significantly associated with piercing in both men and women. Jewelry was the most common source.
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Authors | Erin M Warshaw, Kelly A Aschenbeck, Joel G DeKoven, Howard I Maibach, James S Taylor, Denis Sasseville, Donald V Belsito, Joseph F Fowler Jr, Kathryn A Zug, Matthew J Zirwas, Anthony F Fransway, Vincent A DeLeo, James G Marks Jr, Melanie D Pratt, Toby Mathias |
Journal | Dermatitis : contact, atopic, occupational, drug
(Dermatitis)
2017 Nov/Dec
Vol. 28
Issue 6
Pg. 333-341
ISSN: 2162-5220 [Electronic] United States |
PMID | 29135681
(Publication Type: Journal Article)
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Chemical References |
- Metals, Heavy
- Chromium
- Cobalt
- Nickel
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Topics |
- Adolescent
- Adult
- Age Factors
- Body Piercing
(adverse effects, statistics & numerical data)
- Child
- Child, Preschool
- Chromium
(adverse effects)
- Cobalt
(adverse effects)
- Cross-Sectional Studies
- Dermatitis, Allergic Contact
(epidemiology, etiology)
- Female
- Humans
- Jewelry
(adverse effects)
- Male
- Metals, Heavy
(adverse effects)
- Middle Aged
- Nickel
(adverse effects)
- North America
(epidemiology)
- Patch Tests
- Retrospective Studies
- Risk Factors
- Sex Factors
- Young Adult
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