PRO-C3: a new and more precise collagen marker for liver fibrosis in patients with chronic hepatitis C.

Abstract

OBJECTIVE:

Detecting significant fibrosis and cirrhosis remains important in treatment and follow-up of patients with chronic hepatitis C Infection (CHC). The aim of this study was to assess the ability of PRO-C3 to identify significant fibrosis (Ishak score ≥3) and cirrhosis (Ishak score ≥5) both as a single test and as a part of algorithms.

MATERIALS AND METHODS:

PRO-C3 was assessed in baseline samples from the NORDynamIC trial. 270 patients were stratified into groups according to baseline biopsy. Baseline APRI, FIB-4 and GUCI scores were available for comparison in 232 patients.

RESULTS:

PRO-C3 increased with Ishak scores (p = .001). Area under the curve (AUC) for significant fibrosis was 0.75 (95% CI 0.68-0.81) and 0.76 (95% CI 0.68-0.84) for cirrhosis. FIB-4, APRI and GUCI had similar AUCs. In a PRO-C3 algorithm including age, platelet count, body mass index (BMI) and international normalised ratio (INR), the diagnostic efficacy improved to 0.85 (CI 0.80-0.89) and 0.90 (IQR 0.84-0.96) for significant fibrosis and cirrhosis, respectively.

CONCLUSIONS:

In our study, PRO-C3 was an independent predictor of fibrosis stage, and may play an important role in managing CHC patients.

• Authors: Janne Fuglsang Hansen, Mette Juul Nielsen, Kristina Nyström, Diana Julie Leeming, Martin Lagging, Gunnar Norkrans, Peer Brehm Christensen, Morten Karsdal
• Journal: Scandinavian journal of gastroenterology (Scand J Gastroenterol) Vol. 53 Issue 1 Pg. 83-87 (Jan 2018) ISSN: 1502-7708 [Electronic] England
• PMID: 29069995 (Publication Type: Journal Article, Multicenter Study)

Chemical References

• Biomarkers
• Collagen Type III

Topics

• Adult
• Area Under Curve
• Biomarkers (blood)
• Collagen Type III (blood)
• Denmark
• Enzyme-Linked Immunosorbent Assay
• Female
• Hepatitis C, Chronic (blood, complications, physiopathology)
• Humans
• Liver (pathology)
• Liver Cirrhosis (diagnosis, etiology)
• Logistic Models
• Male
• Middle Aged
• Predictive Value of Tests
• Randomized Controlled Trials as Topic