Recurrent Kikuchi-Fujimoto Disease Successfully Treated by the Concomitant Use of Hydroxychloroquine and Corticosteroids.

Abstract

Kikuchi-Fujimoto disease (KFD) is a benign disease of unknown etiology characterized by lymphadenopathy and a fever. For the majority of patients with KFD, the course is self-limited; however, the optimum method of managing recurrent cases has not yet been established. We herein report a case of a 42-year-old Japanese woman with KFD (confirmed by a lymph node biopsy). Although high-dose prednisolone (PSL) rapidly induced remission, she experienced four recurrences on treatment tapering. Concomitant use of hydroxychloroquine (HCQ) with low-dose PSL induced continuous remission. This is the first case to suggest the effectiveness of HCQ for recurrent KFD in a Japanese patient.

• Authors: Fumika Honda, Hiroto Tsuboi, Hirofumi Toko, Ayako Ohyama, Hidenori Takahashi, Saori Abe, Masahiro Yokosawa, Hiromitsu Asashima, Shinya Hagiwara, Tomoya Hirota, Yuya Kondo, Isao Matsumoto, Takayuki Sumida
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 56 Issue 24 Pg. 3373-3377 (Dec 15 2017) ISSN: 1349-7235 [Electronic] Japan
• PMID: 29021444 (Publication Type: Case Reports, Journal Article)

Chemical References

• Immunosuppressive Agents
• Hydroxychloroquine
• Prednisolone

Topics

• Adult
• Dose-Response Relationship, Drug
• Drug Therapy, Combination
• Female
• Histiocytic Necrotizing Lymphadenitis (drug therapy)
• Humans
• Hydroxychloroquine (administration & dosage, therapeutic use)
• Immunosuppressive Agents (administration & dosage, therapeutic use)
• Prednisolone (administration & dosage, therapeutic use)
• Recurrence