Abstract | BACKGROUND: METHODS: Male Wistar rats were used to induce hypertension by the administration of L-NAME (a non-pecific nitric oxide inhibitor) (50 mg/kg/day). The others groups were receiving concomitantly L-NAME plus Bp extract (75 and 150 mg/kg/day) or losartan (25 mg/kg/day). All the treatments were given orally for 4 weeks. At the end of the treatment, the hemodynamic parameters were recorded using the direct cannulation method. The effects of the extract on lipid profile, kidney and liver functions as well as oxidative stress markers were evaluated by colorimetric method. Results were expressed as the mean ± SEM. The difference between the groups was compared using one-way analysis of variance (ANOVA) followed by the Duncan's post hoc test. RESULTS: Animals receiving L-NAME presented high blood pressure, normal heart rate and lipid profile as well as NO depletion, liver and kidney injuries and oxidative stress. The concomitant treatment with L-NAME and Bp or losartan succeeded to prevent the raised of blood pressure and all the other injuries without affecting the heart rate. CONCLUSION:
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Authors | Danielle Claude Bilanda, Paul Désiré D Dzeufiet, Léontine Kouakep, Bibi Farouck O Aboubakar, Léonard Tedong, Pierre Kamtchouing, Théophile Dimo |
Journal | BMC complementary and alternative medicine
(BMC Complement Altern Med)
Vol. 17
Issue 1
Pg. 479
(Oct 10 2017)
ISSN: 1472-6882 [Electronic] England |
PMID | 29017485
(Publication Type: Journal Article)
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Chemical References |
- Acetates
- Ethylenes
- Lipids
- Plant Extracts
- Protective Agents
- ethylene
- NG-Nitroarginine Methyl Ester
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Topics |
- Acetates
- Animals
- Bidens
(chemistry)
- Ethylenes
- Hypertension
(metabolism, prevention & control)
- Kidney
(drug effects)
- Lipids
- Liver
(drug effects)
- NG-Nitroarginine Methyl Ester
- Oxidative Stress
(drug effects)
- Plant Extracts
(chemistry, pharmacology)
- Protective Agents
(chemistry, pharmacology)
- Rats, Wistar
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