Independent Prognostic Value of Hypoxia-inducible Factor 1-alpha Expression in Small Cell Lung Cancer.

Abstract

Hypoxia is an important factor in tumor angiogenesis, metastasis, and resistance to chemotherapy or radiotherapy, and may be an indicator of poor prognosis. The transcription factor hypoxia-inducible factor 1 (HIF-1) is the key regulator of the hypoxic state. This study was designed to evaluate the prognostic value of HIF-1α expression in small cell lung cancer (SCLC). Forty-three paraffin-embedded biopsy materials were examined using immunohistochemistry. Our results indicated that the expression of HIF-1α was high in males, and patients with poor Eastern Cooperative Oncology Group (ECOG) performance status and metastases. To elucidate the prognostic value of HIF-1α expression, Kaplan-Meier analysis was carried out and the results showed that patients with high HIF-1α expression had a poorer prognosis than patients with low expression of HIF-1α. After adjusting clinical parameters by the Cox proportional hazards model, our results demonstrated that high HIF-1α expression is an independent prognostic factor for SCLC with a 39.2-fold risk of death (p<0.003). In conclusion, we have provided evidence that HIF-1α expression has significant value in predicting survival of patients with SCLC and is an independent prognostic factor beyond ECOG performance and metastasis status.

• Authors: Chang-Sheng Lin, Tu-Chen Liu, Ming-Tsung Lee, Shun-Fa Yang, Thomas Chang-Yao Tsao
• Journal: International journal of medical sciences (Int J Med Sci) Vol. 14 Issue 8 Pg. 785-790 ( 2017) ISSN: 1449-1907 [Electronic] Australia
• PMID: 28824314 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• HIF1A protein, human
• Hypoxia-Inducible Factor 1, alpha Subunit

Topics

• Aged
• Aged, 80 and over
• Biomarkers, Tumor (genetics)
• Drug Resistance, Neoplasm (genetics)
• Female
• Gene Expression Regulation, Neoplastic
• Humans
• Hypoxia-Inducible Factor 1, alpha Subunit (genetics)
• Kaplan-Meier Estimate
• Male
• Middle Aged
• Neoplasm Metastasis
• Neovascularization, Pathologic (diagnosis, genetics, pathology)
• Prognosis
• Proportional Hazards Models
• Small Cell Lung Carcinoma (genetics, mortality, pathology)