Adherence to a Gluten-free Diet: Assessment by Dietician Interview and Serology.

Abstract

We aimed to determine whether tissue transglutaminase (tTG) autoantibody positivity was associated with dietitian-assessed adherence to a gluten-free diet in pediatric patients with celiac disease and identify areas where adherence falters. We reviewed the records of children with celiac disease who had a standardized evaluation of adherence by a registered dietitian. A negative tTG value was not associated with good adherence (P = NS). Adherent and nonadherent children differed with respect to purposeful and accidental gluten exposure (P < 0.0001), knowledge (P = 0.003), cross-contact (P = 0.003), potential exposure via medications and cosmetics (P = 0.004), and potential exposure while at restaurants (P < 0.0001), but not with respect to potential exposure at school (P = NS). Based on our findings, we suggest that negative tTG levels are not necessarily indicative of good adherence to a gluten-free diet in pediatric patients with celiac disease. A separate assessment of adherence is needed focusing on knowledge, behavior while dining out, and intent to adhere.

• Authors: Pooja Mehta, Zhaoxing Pan, Marisa D Riley, Edwin Liu
• Journal: Journal of pediatric gastroenterology and nutrition (J Pediatr Gastroenterol Nutr) Vol. 66 Issue 3 Pg. e67-e70 (03 2018) ISSN: 1536-4801 [Electronic] United States
• PMID: 28806297 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Autoantibodies
• Biomarkers
• Protein Glutamine gamma Glutamyltransferase 2
• Transglutaminases
• GTP-Binding Proteins

Topics

• Adolescent
• Autoantibodies (blood)
• Biomarkers (blood)
• Celiac Disease (blood, diagnosis, diet therapy, psychology)
• Child
• Child, Preschool
• Diet, Gluten-Free (psychology)
• Female
• Follow-Up Studies
• GTP-Binding Proteins (immunology)
• Health Knowledge, Attitudes, Practice
• Humans
• Male
• Nutritionists
• Patient Compliance (psychology, statistics & numerical data)
• Protein Glutamine gamma Glutamyltransferase 2
• Transglutaminases (immunology)
• Young Adult