Associations between tooth loss and prognostic biomarkers and the risk for cardiovascular events in patients with stable coronary heart disease.

Abstract

BACKGROUND:

Underlying mechanisms behind the hypothesized relationship between periodontal disease (PD) and coronary heart disease (CHD) have been insufficiently explored. We evaluated associations between self-reported tooth loss- a marker of PD- and prognostic biomarkers in 15,456 (97%) patients with stable CHD in the global STABILITY trial.

METHODS AND RESULTS:

Baseline blood samples were obtained and patients reported their number of teeth according to the following tooth loss levels: "26-32 (All)" [lowest level], "20-25", "15-19", "1-14", and "No Teeth" [highest level]. Linear and Cox regression models assessed associations between tooth loss levels and biomarker levels, and the relationship between tooth loss levels and outcomes, respectively. After multivariable adjustment, the relative biomarker increase between the highest and the lowest tooth loss level was: high-sensitivity C-reactive protein 1.21 (95% confidence interval, 1.14-1.29), interleukin 6 1.14 (1.10-1.18), lipoprotein-associated phospholipase A2 activity 1.05 (1.03-1.06), growth differentiation factor 15 1.11 (1.08-1.14), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) 1.18 (1.11-1.25). No association was detected for high-sensitivity troponin T 1.02 (0.98-1.05). Some attenuation of the relationship between tooth loss and outcomes resulted from the addition of biomarkers to the multivariable analysis, of which NT-proBNP had the biggest impact.

CONCLUSIONS:

A graded and independent association between tooth loss and several prognostic biomarkers was observed, suggesting that tooth loss and its underlying mechanisms may be involved in multiple pathophysiological pathways also implicated in the development and prognosis of CHD. The association between tooth loss and cardiovascular death and stroke persisted despite comprehensive adjustment including prognostic biomarkers.

CLINICAL TRIAL REGISTRATION:

www.clinicaltrials.gov; NCT00799903.

• Authors: Ola Vedin, Emil Hagström, Ollie Östlund, Alvaro Avezum, Andrzej Budaj, Marcus D Flather, Robert A Harrington, Wolfgang Koenig, Joseph Soffer, Agneta Siegbahn, Philippe Gabriel Steg, Ralph A H Stewart, Lars Wallentin, Harvey D White, Claes Held, STABILITY Investigators
• Journal: International journal of cardiology (Int J Cardiol) Vol. 245 Pg. 271-276 (Oct 15 2017) ISSN: 1874-1754 [Electronic] Netherlands
• PMID: 28735759 (Publication Type: Clinical Trial, Journal Article)
• Copyright: Copyright © 2017 Elsevier B.V. All rights reserved.

Chemical References

• Biomarkers
• Peptide Fragments
• pro-brain natriuretic peptide (1-76)
• Natriuretic Peptide, Brain
• C-Reactive Protein

Topics

• Aged
• Biomarkers (blood)
• C-Reactive Protein (metabolism)
• Cardiovascular Diseases (blood, diagnosis, epidemiology)
• Coronary Disease (blood, diagnosis, epidemiology)
• Cross-Sectional Studies
• Female
• Humans
• Male
• Middle Aged
• Natriuretic Peptide, Brain (blood)
• Peptide Fragments (blood)
• Prognosis
• Risk Factors
• Self Report
• Tooth Loss (blood, diagnosis, epidemiology)