Predictors of mortality in Middle East respiratory syndrome (MERS).

Abstract

We evaluated the clinical characteristics, cytokine/chemokine concentrations, viral shedding and antibody kinetics in 30 patients with Middle East respiratory syndrome (MERS), including 6 non-survivors admitted to 3 MERS-designated hospitals. Old age, low albumin, altered mentality and high pneumonia severity index score at admission were risk factors for mortality. In addition, severe signs of inflammation at initial presentation (at hospital days 1-4), such as high inducible protein-10 (p=0.0013), monocyte chemoattractant protein-1 (p=0.0007) and interleukin 6 (p=0.0007) concentrations, and poor viral control (high viral load at hospital days 5-10, p<0.001) without adequate antibody titres (low antibody titre at hospital days 11-16, p=0.07) during the course of disease, were associated with mortality.

• Authors: Ki-Ho Hong, Jae-Phil Choi, Seon-Hui Hong, Jeewon Lee, Ji-Soo Kwon, Sun-Mi Kim, Se Yoon Park, Ji-Young Rhee, Baek-Nam Kim, Hee Jung Choi, Eui-Cheol Shin, Hyunjoo Pai, Su-Hyung Park, Sung-Han Kim
• Journal: Thorax (Thorax) Vol. 73 Issue 3 Pg. 286-289 (03 2018) ISSN: 1468-3296 [Electronic] England
• PMID: 28724637 (Publication Type: Letter, Research Support, Non-U.S. Gov't)
• Copyright: © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Chemical References

• Antibodies, Viral
• Cytokines

Topics

• Antibodies, Viral (blood)
• Coronavirus (genetics)
• Coronavirus Infections (mortality)
• Cytokines (blood)
• Female
• Humans
• Male
• Middle Aged
• Real-Time Polymerase Chain Reaction
• Risk Factors
• Survival Rate
• Viral Load (genetics)