Tumor-induced osteomalacia (TIO) is a debilitating paraneoplastic condition caused by small phosphaturic mesenchymal
tumors (
PMTs) that secrete large amounts of the
phosphate-regulating and
vitamin D-regulating
hormone, FGF23.
Tumor removal results in cure. However, because of high perioperative comorbidity, either from
tumor location or host factors, surgery is sometimes not an option.
Tumor destruction via
cryoablation may be an effective option for inoperable
PMTs. Three subjects with a confirmed diagnosis of TIO were studied. All three underwent
cryoablation of suspected
PMTs rather than surgery due to significant medical comorbidities or challenging anatomical location. Subject 3 had
tumor embolization 24 hours prior to
cryoablation because of the size and hypervascularity of the
tumor. The success of the
tumor cryoablation was defined by normalization of serum
phosphate and FGF23.
Cryoablation resulted in a rapid decrease in plasma intact FGF23 by 24 hours postprocedure in all three subjects (0, 2, and 9 pg/mL, respectively) with normalization of blood
phosphate by postprocedure day 3. Three-day renal tubular reabsorption of
phosphate increased to 76%, 94%, and 95.2%, respectively; 1, 25(
OH)2
vitamin D increased to 84, 138, and 196 pg/ml, respectively. All three had dramatic clinical improvement in
pain and weakness. Two subjects tolerated the procedure well with no complications; one had significant prolonged procedure-related localized
pain. Although surgery remains the treatment of choice,
cryoablation may be an effective, less invasive, and safe treatment for patients with difficult to remove
tumors or who are poor surgical candidates. © 2017 American Society for Bone and
Mineral Research.