Effects of denosumab treatment on bone mineral density and joint destruction in patients with rheumatoid arthritis.

Abstract

We aimed to investigate the efficacy of denosumab for rheumatoid arthritis (RA). This study enrolled 70 RA patients who received denosumab 60 mg subcutaneous injection at baseline and at 6 months. Bone mineral densities (BMD) of the lumbar spine, total hip, femoral neck, and hand were measured by dual energy X-ray absorptiometry. Changes in total modified Sharp score (mTSS), erosion (EN) score, and joint space narrowing score at baseline from 12 months before and at 12 months from baseline. The mean values of BMD of the lumbar spine, total hip, femoral neck, and hand significantly increased by 7.3, 4.7, 3.9, and 5.4%, respectively, at 12 months. At 12 months from baseline, there were significant decreases in the values of mTSS (1.13 vs. 0.59; p = 0.002) and EN score (0.40 vs. 0.07; p < 0.001), compared with the values at baseline from 12 months before. The existing combined modality therapy with denosumab might be effective for osteoporosis and joint destruction in patients with RA.

• Authors: Takeshi Mochizuki, Koichiro Yano, Katsunori Ikari, Kosei Kawakami, Ryo Hiroshima, Naoko Koenuma, Mina Ishibashi, Shigeki Momohara
• Journal: Journal of bone and mineral metabolism (J Bone Miner Metab) Vol. 36 Issue 4 Pg. 431-438 (Jul 2018) ISSN: 1435-5604 [Electronic] Japan
• PMID: 28681148 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Denosumab

Topics

• Aged
• Arthritis, Rheumatoid (drug therapy)
• Bone Density (drug effects)
• Demography
• Denosumab (pharmacology, therapeutic use)
• Female
• Femur Neck (drug effects, pathology)
• Humans
• Joints (drug effects, pathology)
• Logistic Models
• Lumbar Vertebrae (drug effects, pathology)
• Male
• Multivariate Analysis