Can the combined administration of labelled fluoro-2 deoxy d glucose and insulin or chrome increase the diagnostic sensitivity of Positron Emission Tomography (PET)?

Abstract

In this letter to editor I hypothesize that administering insulin or chrome along with fluoro-2 deoxy d-glucose (FDG) to enhance its uptake in malignant lesions that are known to have low levels of tumor glycolysis, and therefore, improve the sensitivity of PET imaging in this setting. The logic behind this idea stems from the known fact that there is substantial increase in uptake of d-glucose following administration of insülin/chrome in many tissues, and as such, the same pattern would apply to FDG.

• Authors: Suleyman Aydin
• Journal: Medical hypotheses (Med Hypotheses) Vol. 104 Pg. 154-155 (Jul 2017) ISSN: 1532-2777 [Electronic] United States
• PMID: 28673575 (Publication Type: Letter)
• Copyright: Copyright © 2017 Elsevier Ltd. All rights reserved.

Chemical References

• Insulin
• Fluorodeoxyglucose F18

Topics

• Fluorodeoxyglucose F18 (administration & dosage)
• Glycolysis
• Humans
• Insulin (administration & dosage, chemistry)
• Models, Theoretical
• Neoplasms (diagnostic imaging)
• Positron-Emission Tomography
• Reproducibility of Results
• Sensitivity and Specificity