Constitutional heparin co-factor II deficiency associated with recurrent thrombosis.

Abstract

The family of a 36-year-old man with recurrent deep venous thrombosis and heparin co-factor II (HC II) deficiency was investigated for this deficiency. The deficiency was inherited as an autosomal dominant trait. 4 members of the family had low HC II levels but only the proband had a history of thromboses; however, 2 of 4 affected were only 14 and 23 years old. The deficiency did not affect the anticoagulant action of heparin, with which the patient was treated.

• Authors: P Sie, D Dupouy, J Pichon, B Boneu
• Journal: Lancet (London, England) (Lancet) Vol. 2 Issue 8452 Pg. 414-6 (Aug 24 1985) ISSN: 0140-6736 [Print] England
• PMID: 2863445 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antigens
• Glycoproteins
• Protein C
• Protein S
• Heparin Cofactor II

Topics

• Adolescent
• Adult
• Antigens (analysis)
• Glycoproteins (analysis, deficiency, genetics, immunology)
• Heparin Cofactor II
• Humans
• Male
• Middle Aged
• Pedigree
• Protein C
• Protein S
• Recurrence
• Thrombophlebitis (blood, genetics)