Risk of pneumonia in obstructive lung disease: A real-life study comparing extra-fine and fine-particle inhaled corticosteroids.

Abstract

BACKGROUND:

Regular use of inhaled corticosteroids (ICS) in patients with obstructive lung diseases has been associated with a higher risk of pneumonia, particularly in COPD. The risk of pneumonia has not been previously evaluated in relation to ICS particle size and dose used.

METHODS:

Historical cohort, UK database study of 23,013 patients with obstructive lung disease aged 12-80 years prescribed extra-fine or fine-particle ICS. The endpoints assessed during the outcome year were diagnosis of pneumonia, acute exacerbations and acute respiratory events in relation to ICS dose. To determine the association between ICS particle size, dose and risk of pneumonia in unmatched and matched treatment groups, logistic and conditional logistic regression models were used.

RESULTS:

14788 patients were stepped-up to fine-particle ICS and 8225 to extra-fine ICS. On unmatched analysis, patients stepping-up to extra-fine ICS were significantly less likely to be coded for pneumonia (adjusted odds ratio [aOR] 0.60; 95% CI 0.37, 0.97]); experience acute exacerbations (adjusted risk ratio [aRR] 0.91; 95%CI 0.85, 0.97); and acute respiratory events (aRR 0.90; 95%CI 0.86, 0.94) compared with patients stepping-up to fine-particle ICS. Patients prescribed daily ICS doses in excess of 700 mcg (fluticasone propionate equivalent) had a significantly higher risk of pneumonia (OR [95%CI] 2.38 [1.17, 4.83]) compared with patients prescribed lower doses, irrespective of particle size.

CONCLUSIONS:

These findings suggest that patients with obstructive lung disease on extra-fine particle ICS have a lower risk of pneumonia than those on fine-particle ICS, with those receiving higher ICS doses being at a greater risk.

• Authors: Samatha Sonnappa, Richard Martin, Elliot Israel, Dirkje Postma, Wim van Aalderen, Annie Burden, Omar S Usmani, David B Price, Respiratory Effectiveness Group, Small Airways Study Group
• Journal: PloS one (PLoS One) Vol. 12 Issue 6 Pg. e0178112 ( 2017) ISSN: 1932-6203 [Electronic] United States
• PMID: 28617814 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Adrenal Cortex Hormones
• Bronchodilator Agents

Topics

• Administration, Inhalation
• Adolescent
• Adrenal Cortex Hormones (administration & dosage, adverse effects)
• Adult
• Aged
• Aged, 80 and over
• Bronchodilator Agents (administration & dosage, adverse effects)
• Child
• Dose-Response Relationship, Drug
• Female
• Humans
• Logistic Models
• Male
• Middle Aged
• Particle Size
• Pharmacovigilance
• Pneumonia (chemically induced, epidemiology)
• Pulmonary Disease, Chronic Obstructive (complications, drug therapy)
• United Kingdom (epidemiology)
• Young Adult