[High Mobility Group Chromosomal Protein N2 Inhibit Cervical Cancer Transplanted in Nude Mice].

Abstract

OBJECTIVES:

To study the effect of high mobility group chromosomal protein N2 on inhibiting cervical cancer in nude mice.

METHODS:

Model of cervical cancer were established in nude mice. They were randomly divided into 4 groups including negative control group, HMGN2 group, cisplatin group and HMGN2 with cisplatin group. After 4 injections, the tumor size were calculated and tumor tissues were stained by haematoxylin eosin (HE) staining.

RESULTS:

Transplated tumor models were established successfully. The tumor sizes of negative control group [(0.38±0.12) cm³] were significantly lower than those of HMGN2 group [(0.14±0.07)cm³, cisplatin group [(0.11±0.06) cm³] and HMGN2 combined with cisplatin group[(0.11±0.07) cm³]. No differences were detected in HMGN2 group, cisplatin group and HMGN2 with cisplatin group in tumor sizes. The tumor inhibition rates of HMGN2 group, cisplatin group and HMGN2 with cisplatin group were 0.62±0.18, 0.71±0.17 and 0.70±0.18, respectively. The necrosis area were smaller in negative control group than in other three groups by HE staining.

CONCLUSIONS:

HMGN2 has a significant inhibitory effect on transplanted cervical cancer in nude mice.

• Authors: Bin Luo, Qian-Wen Zhang, Yu Xu, Jian Meng, Xiao-Li Wang, Lin Li, Yue-Dong He
• Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition (Sichuan Da Xue Xue Bao Yi Xue Ban) Vol. 47 Issue 5 Pg. 718-721 (Sep 2016) ISSN: 1672-173X [Print] China
• PMID: 28598086 (Publication Type: Journal Article)

Chemical References

• HMGN2 Protein
• Cisplatin

Topics

• Animals
• Cell Line, Tumor
• Cisplatin (pharmacology)
• Female
• HMGN2 Protein (pharmacology)
• Humans
• Mice
• Mice, Nude
• Uterine Cervical Neoplasms (drug therapy)
• Xenograft Model Antitumor Assays