Evaluation of Corneal Endothelial Cell Loss After Uncomplicated Phacoemulsification Cataract Surgery With Intracameral Phenylephrine.

Abstract

PURPOSE:

To study the effects of intracameral phenylephrine 1.5% on corneal endothelial cell loss and morphological changes in patients who had uneventful phacoemulsification surgery.

DESIGN:

A double-blind randomized controlled trial.

METHODS:

This study comprised 295 patients who were randomized into the intracameral (ICM) mydriatic group or topical mydriatic group. Central corneal endothelial cell density (ECD), coefficient of variation (CV), and percentage of hexagonal cells were measured preoperatively and postoperatively at 1 week, 6 weeks, and 3 months with specular microscope.

RESULTS:

There was no significant difference in endothelial cell density and endothelial cell loss between the topical and ICM mydriatic groups. At 3 months, the mean endothelial cell density in the ICM group was 2129.76 ± 423.53 cells/mm2 and 2100.54 ± 393.00 cells/mm2 in the topical group (P = 0.539). The endothelial cell loss was 18.60 ± 12.79% in the IC M group and 19.44 ± 11.24% in the topical group (P = 0.550). No significant difference was seen in the percentage of hexagonal cells and coefficient of variation of patients between the 2 groups.

CONCLUSIONS:

Intracameral phenylephrine was not associated with increased risk of postoperative endothelial cell loss or morphological changes. It can be safely injected into the anterior chamber for pupil dilatation before phacoemulsification cataract surgery.

• Authors: Li Sar Teoh, Siu Wan Foo, Vanessa Naseem Mansurali, Ee Ling Ang, Umi Kalthum Md Noh, Mae-Lynn Catherine Bastion
• Journal: Asia-Pacific journal of ophthalmology (Philadelphia, Pa.) (Asia Pac J Ophthalmol (Phila)) 2017 Jul-Aug Vol. 6 Issue 4 Pg. 318-325 ISSN: 2162-0989 [Electronic] China
• PMID: 28581284 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: Copyright 2017 Asia-Pacific Academy of Ophthalmology.

Chemical References

• Mydriatics
• Phenylephrine

Topics

• Aged
• Anterior Chamber
• Cell Count
• Corneal Endothelial Cell Loss (diagnosis, etiology, prevention & control)
• Double-Blind Method
• Endothelium, Corneal (pathology)
• Female
• Follow-Up Studies
• Humans
• Injections
• Intraoperative Period
• Male
• Mydriatics (administration & dosage)
• Phacoemulsification (methods)
• Phenylephrine (administration & dosage)
• Prospective Studies