We aimed to investigate (1) the relationship between
cognitive impairment (CI) and disease severity and (2) the potential differences in exercise performance, daily activities, health status, and psychological well-being between patients with and without CI. Clinically stable
chronic obstructive pulmonary disease (
COPD) patients, referred for pulmonary rehabilitation, underwent a neuropsychological examination. Functional exercise capacity (6-minute walk test [6MWT]), daily activities (Canadian Occupational Performance Measure [COPM]), health status (
COPD Assessment Test [CAT]) and St George's Respiratory Questionnaire-
COPD specific [SGRQ-C]), and psychological well-being (Hospital Anxiety and Depression Scale [
HADS], Beck Depression Inventory [BDI], and Symptom Checklist 90 [SCL-90]) were compared between patients with and without CI. Of 183
COPD patients (mean age 63.6 (9.4) years, FEV1 54.8 (23.0%) predicted), 76 (41.5%) patients had CI. The prevalence was comparable across Global Initiative for
Chronic Obstructive Lung Disease (
GOLD) grades 1-4 (44.8%, 40.0%, 41.0%, 43.5%, respectively, p = 0.97) and
GOLD groups A-D (50.0%, 44.7%, 33.3%, 40.2%, respectively, p = 0.91). Patients with and without CI were comparable for demographics, smoking status, FEV1% predicted, mMRC, 6MWT, COPM, CAT,
HADS, BDI, and SCL-90 scores. Clinical characteristics of
COPD patients with and without CI are comparable. Assessment of CI in
COPD, thus, requires an active case-finding approach.