Parkinson's disease (PD) was characterized by late-onset, progressive dopamine neuron loss and
movement disorders. The progresses of PD affected the neural function and integrity. To date, most researches had largely addressed the
dopamine replacement
therapies, but the appearance of
L-dopa-induced
dyskinesia hampered the use of the drug. And the mechanism of PD is so complicated that it's hard to solve the problem by just add drugs. Researchers began to focus on the genetic underpinnings of
Parkinson's disease, searching for new method that may affect the neurodegeneration processes in it. In this paper, we reviewed current delivery methods used in gene
therapies for PD, we also summarized the primary target of the gene therapy in the treatment of PD, such like
neurotrophic factor (for regeneration), the synthesis of
neurotransmitter (for prolong the duration of
L-dopa), and the potential
proteins that might be a target to modulate via gene therapy. Finally, we discussed RNA interference
therapies used in
Parkinson's disease, it might act as a new class of drug. We mainly focus on the efficiency and tooling features of different gene
therapies in the treatment of PD.