A Proposal for a Study on Treatment Selection and Lifestyle Recommendations in Chronic Inflammatory Diseases: A Danish Multidisciplinary Collaboration on Prognostic Factors and Personalised Medicine.

Abstract

Chronic inflammatory diseases (CIDs), including Crohn's disease and ulcerative colitis (inflammatory bowel diseases, IBD), rheumatoid arthritis, psoriasis, psoriatic arthritis, spondyloarthritides, hidradenitis suppurativa, and immune-mediated uveitis, are treated with biologics targeting the pro-inflammatory molecule tumour necrosis factor-α (TNF) (i.e., TNF inhibitors). Approximately one-third of the patients do not respond to the treatment. Genetics and lifestyle may affect the treatment results. The aims of this multidisciplinary collaboration are to identify (1) molecular signatures of prognostic value to help tailor treatment decisions to an individual likely to initiate TNF inhibitor therapy, followed by (2) lifestyle factors that support achievement of optimised treatment outcome. This report describes the establishment of a cohort that aims to obtain this information. Clinical data including lifestyle and treatment response and biological specimens (blood, faeces, urine, and, in IBD patients, intestinal biopsies) are sampled prior to and while on TNF inhibitor therapy. Both hypothesis-driven and data-driven analyses will be performed according to pre-specified protocols including pathway analyses resulting from candidate gene expression analyses and global approaches (e.g., metabolomics, metagenomics, proteomics). The final purpose is to improve the lives of patients suffering from CIDs, by providing tools facilitating treatment selection and dietary recommendations likely to improve the clinical outcome.

• Authors: Vibeke Andersen, Uffe Holmskov, Signe Bek Sørensen, Mohamad Jawhara, Karina W Andersen, Anette Bygum, Lone Hvid, Jakob Grauslund, Jimmi Wied, Henning Glerup, Ulrich Fredberg, Jan Alexander Villadsen, Søren Geill Kjær, Jan Fallingborg, Seyed A G R Moghadd, Torben Knudsen, Jacob Brodersen, Jesper Frøjk, Jens F Dahlerup, Ole Haagen Nielsen, Robin Christensen, Anders Bo Bojesen, Grith Lykke Sorensen, Steffen Thiel, Nils J Færgeman, Ivan Brandslund, Allan Stensballe, Erik Berg Schmidt, Andre Franke, David Ellinghaus, Philip Rosenstiel, Jeroen Raes, Berit Heitmann, Mette Boye, Charlotte Lindgaard Nielsen, Lars Werner, Jens Kjeldsen, Torkell Ellingsen
• Journal: Nutrients (Nutrients) Vol. 9 Issue 5 (May 15 2017) ISSN: 2072-6643 [Electronic] Switzerland
• PMID: 28505128 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Dietary Fats
• Dietary Fiber
• Dietary Proteins
• Fatty Acids, Unsaturated
• Micronutrients
• Tumor Necrosis Factor-alpha

Topics

• Biomarkers (blood)
• Body Mass Index
• Denmark
• Diet
• Dietary Fats (administration & dosage)
• Dietary Fiber (administration & dosage)
• Dietary Proteins (administration & dosage)
• Exercise
• Fatty Acids, Unsaturated (administration & dosage)
• Female
• Follow-Up Studies
• Gene-Environment Interaction
• Humans
• Inflammatory Bowel Diseases (diagnosis, diet therapy, drug therapy)
• Intestinal Mucosa (metabolism)
• Life Style
• Male
• Meat
• Micronutrients (administration & dosage)
• Precision Medicine
• Prospective Studies
• Smoking (therapy)
• Tumor Necrosis Factor-alpha (antagonists & inhibitors)