Abstract | INTRODUCTION: METHODS: Patients were genotyped for four different polymorphisms of the NEUROD2 gene ((rs9889354(A/G), rs1877032(C/T), rs12453682(C/T) and rs11078918(C/G)). Cognitive function was assessed at baseline and week 8. Results of individual neuropsychological tests were assigned to six cognitive domains (reaction time and quality; executive function; working, verbal and visual memory) and a general cognitive index. RESULTS: 167 patients were included in the study. The NEUROD2 exonic polymorphism rs11078918 showed significant associations with verbal memory and executive functions, whereas the NEUROD2 polymorphism rs12453682 was significantly associated with working and verbal memory, executive functions and with a cognitive index. Significant associations were found at baseline and after eight weeks. Moreover, significant associations between the change in neuropsychological test results during antipsychotic treatment and the NEUROD2 polymorphisms rs11078918 and rs12453682 were observed. CONCLUSIONS:
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Authors | Ilja Spellmann, Michael Riedel, Julia Städtler, Peter Zill, Michael Obermeier, Anja Cerovecki, Sandra Dehning, Rebecca Schennach, Maria Epple, Markus Opgen-Rhein, Norbert Müller, Brigitta Bondy, Hans-Jürgen Möller, Richard Musil |
Journal | Cognitive neuropsychiatry
(Cogn Neuropsychiatry)
Vol. 22
Issue 4
Pg. 280-297
(Jul 2017)
ISSN: 1464-0619 [Electronic] England |
PMID | 28470106
(Publication Type: Journal Article)
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Chemical References |
- Antipsychotic Agents
- Basic Helix-Loop-Helix Transcription Factors
- NEUROD2 protein, human
- Neuropeptides
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Topics |
- Adult
- Antipsychotic Agents
(therapeutic use)
- Basic Helix-Loop-Helix Transcription Factors
(genetics)
- Cognition
(physiology)
- Cognition Disorders
(genetics, physiopathology)
- Executive Function
(physiology)
- Female
- Genotype
- Humans
- Male
- Memory
(physiology)
- Middle Aged
- Neuropeptides
(genetics)
- Neuropsychological Tests
- Polymorphism, Genetic
- Psychotic Disorders
(drug therapy, genetics, physiopathology, psychology)
- Reaction Time
- Schizophrenia
(drug therapy, genetics, physiopathology)
- Schizophrenic Psychology
- Young Adult
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