Radiation and Thyroid Cancer.

Abstract

Radiation-induced damage is a complex network of interlinked signaling pathways, which may result in apoptosis, cell cycle arrest, DNA repair, and cancer. The development of thyroid cancer in response to radiation, from nuclear catastrophes to chemotherapy, has long been an object of study. A basic overview of the ionizing and non-ionizing radiation effects of the sensitivity of the thyroid gland on radiation and cancer development has been provided. In this review, we focus our attention on experiments in cell cultures exposed to ionizing radiation, ultraviolet light, and proton beams. Studies on the involvement of specific genes, proteins, and lipids are also reported. This review also describes how lipids are regulated in response to the radiation-induced damage and how they are involved in thyroid cancer etiology, invasion, and migration and how they can be used as both diagnostic markers and drug targets.

• Authors: Elisabetta Albi, Samuela Cataldi, Andrea Lazzarini, Michela Codini, Tommaso Beccari, Francesco Saverio Ambesi-Impiombato, Francesco Curcio
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 18 Issue 5 (Apr 26 2017) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 28445397 (Publication Type: Journal Article, Review)

Chemical References

• Biomarkers
• Reactive Oxygen Species

Topics

• Animals
• Apoptosis (radiation effects)
• Biomarkers (metabolism)
• Humans
• Lipid Metabolism (radiation effects)
• Radiation, Ionizing
• Reactive Oxygen Species (metabolism)
• Signal Transduction (radiation effects)
• Thyroid Gland (pathology, radiation effects)
• Thyroid Neoplasms (etiology)
• Ultraviolet Rays