Abstract | BACKGROUND: OBJECTIVE: Perform a focus literature review evaluating the prevalence of the CD30 antigen among nonlymphomatous tumors with a potential correlate for CD30 targeted therapy. ELIGIBILITY CRITERIA: Inclusion criteria: all retrospective reviews and case reports citing CD30 positivity or negativity in non-lymphomatous malignancies in which data were presented based on location. EXCLUSION CRITERIA: INCLUDED STUDIES: A total of 119 articles met these criteria and are summarized in this manuscript. CONCLUSION: The CD30 antigen has shown variable prevalence among non-hematopoetic tumors, most notably among germ cell tumors and mesothelioma. With additional, preclinical and properly powered clinical studies, CD30 targeted therapy such as that of BV, alone or in combination with other agents may prove to be a strong candidate in the treatment of various CD30+ malignancies.
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Authors | Garrett K Berger, Kevin Gee, Cassandra Votruba, Ali McBride, Faiz Anwer |
Journal | Critical reviews in oncology/hematology
(Crit Rev Oncol Hematol)
Vol. 113
Pg. 8-17
(May 2017)
ISSN: 1879-0461 [Electronic] Netherlands |
PMID | 28427526
(Publication Type: Journal Article, Review)
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Copyright | Copyright © 2017 Elsevier B.V. All rights reserved. |
Chemical References |
- Antineoplastic Agents
- Immunoconjugates
- Ki-1 Antigen
- Brentuximab Vedotin
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Topics |
- Antineoplastic Agents
(therapeutic use)
- Brentuximab Vedotin
- Humans
- Immunoconjugates
(therapeutic use)
- Immunotherapy
- Ki-1 Antigen
(immunology)
- Neoplasms
(drug therapy, metabolism)
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