Ki-1 Antigen

A member of the tumor necrosis factor receptor superfamily that may play a role in the regulation of NF-KAPPA B and APOPTOSIS. It is found on activated T-LYMPHOCYTES; B-LYMPHOCYTES; NEUTROPHILS; EOSINOPHILS; MAST CELLS and NK CELLS. Overexpression of the Ki-1 antigen in hematopoietic malignancies make it clinically useful as a biological tumor marker. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.

Also Known As:

Networked: 229 relevant articles (7 outcomes, 19 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Papadopoulos, N: 4 articles (01/2006 - 01/2001)
2.	Tamiolakis, D: 4 articles (01/2006 - 01/2001)
3.	Dotti, Gianpietro: 3 articles (01/2022 - 06/2009)
4.	Savoldo, Barbara: 3 articles (01/2022 - 06/2009)
5.	Horny, Hans-Peter: 3 articles (12/2015 - 04/2011)
6.	Sotlar, Karl: 3 articles (12/2015 - 04/2011)
7.	Valent, Peter: 3 articles (12/2015 - 04/2011)
8.	Kouskoukis, C: 3 articles (01/2006 - 01/2005)
9.	Koutsougeras, G: 3 articles (01/2006 - 01/2005)
10.	Lambropoulou, M: 3 articles (01/2006 - 01/2005)

Related Diseases

1.	Hodgkin Disease (Hodgkin's Disease) 01/01/2021 - "CD30 antigen, expressed in Hodgkin lymphoma cells, is absent in most healthy tissues, representing an ideal target of ACT for this disease. " 07/01/2002 - "Expression of CD30 antigen is a distinct marker of lymphocyte activation that was originally described in the Reed-Sternberg cells of Hodgkin's disease. " 05/01/1998 - "Biopsy specimens of this lesion revealed intracerebral Hodgkin's lymphoma, a diagnosis supported by immunohistochemical reactions of the tumour cells for the CD30 antigen. " 12/01/1994 - "The CD30 antigen was originally described as a specific surface marker for Hodgkin's lymphoma. " 12/01/1993 - "To assess the effect of microwave heating on immunohistochemical staining of CD15 and CD30 antigens in Hodgkin's disease tissue samples. "
2.	Neoplasms (Cancer) 01/01/1989 - "The expression of Ki-1 antigen by most tumor cells was the distinctive immunologic character of this disorder which helped to clarify the pathological diagnosis. " 01/01/2022 - "The extracellular fragment gene sequences of CD30 were obtained from tumor tissues of PTCL patients and cloned into a plasmid vector to express the CD30 antigen. " 10/08/2021 - "Immunohistochemical staining showed that the tumor cells were positive for pan-B cell antigens, CD30 (77.4%, 24/31), CD23 (73.1%, 19/26), MUM1 (45.8%, 11/24), Ki-67 index ≥70 % (90.6%, 29/32). " 06/01/2019 - "C-ALCL is comprised of large cells with anaplastic, pleomorphic, or immunoblastic cytomorphology, and indeed, more than 75% of the tumor cells express the CD30 antigen. " 05/01/2017 - "The CD30 antigen also has been identified in many solid tumors, predominantly of germ cell origins and early clinical data is promising. "
3.	Lymphoma (Lymphomas) 12/01/1992 - "A significantly greater proportion of cases of ALC lymphoma compared with HD exhibited positive results for CD45, EMA, CD45RO, and CD3 in CD30-positive atypical large cells, whereas Reed-Sternberg cells in HD most frequently coexpressed CD15 and CD30 antigens. " 03/01/2017 - "The present study aimed to investigate the expression of tumor necrosis factor receptor superfamily member 8 (CD30) in extranodal natural killer/T-cell lymphoma (ENKTL) using immunohistochemistry, and to evaluate the association between CD30 and clinicopathological and prognostic significance. " 09/14/2012 - "Like several human lymphomas the neoplastic MD lymphoma cells overexpress the CD30 antigen (CD30(hi)) and are in minority, while the non-neoplastic cells (CD30(lo)) form the majority of population. " 01/01/2012 - "They bound with high specificity to both recombinant antigen CD30 and to CD30(+) lymphoma cells. " 07/01/2004 - "Frequent expression of CD30 antigen in the primary gastric non-B, non-Hodgkin lymphomas."
4.	Non-Hodgkin Lymphoma (Lymphosarcoma) 06/01/1994 - "CD30 antigen in non-Hodgkin's lymphoma." 10/01/1992 - "[Non-Hodgkin lymphoma with Ki-1 antigen: a case report]." 09/01/1990 - "Ki-1 antigen expression defines a favorable clinical subset of non-B cell non-Hodgkin's lymphoma." 12/01/1989 - "A subtype of non-Hodgkin's lymphoma, which expresses the Ki-1 antigen (CD30) and has distinct morphologic and clinical features, has recently been described. " 07/01/1988 - "This is to our knowledge the first Ki-1 antigen-positive line to be established from a case of non-Hodgkin's lymphoma."
5.	Peripheral T-Cell Lymphoma (Lymphoma, T Cell, Peripheral) 01/01/2020 - "Systemic anaplastic large cell lymphoma (sALCL) is a rare histological entity expressing the CD30 antigen that comprises around 11% of peripheral T-cell lymphoma. " 01/01/1993 - "Pleomorphic T cell lymphoma of the medium to large cell type expressing CD30 antigen is a most aggressive peripheral T cell lymphoma. " 10/01/1990 - "We recognized five clinicopathologic subtypes: type I, classical cutaneous T cell lymphoma (CTCL) or mycosis fungoides, six cases; type II, primary large cell type CTCL, Ki-1 antigen (Ki-1+ or Ki-1-), seven cases; type III, primary angioinvasive T cell lymphoma, three cases; type IV, human T-lymphotropic virus type I (HTLV-I+) adult T cell leukemia/lymphoma (ATL), eight cases; type V, secondary cutaneous involvement by peripheral T cell lymphoma (PTL), 19 cases. " 10/01/2022 - "The safety and efficacy of brentuximab vedotin (BV), an antibody-drug conjugate directed to the CD30 antigen, has been assessed in several trials in patients with peripheral T-cell lymphoma (PTCL), cutaneous T-cell lymphoma (CTCL), or B-cell non-Hodgkin lymphoma (NHL). " 08/01/1994 - "We applied EBER-ISH to 846 paraffin embedded specimens, including cases of reactive lymphoid hyperplasia (n = 28), infectious mononucleosis (16), Burkitt's lymphoma (44), immunodeficiency-associated lymphomas in transplant recipients (9) and AIDS patients (128), Hodgkin's disease (130), CD30 antigen positive lymphomas (106), peripheral T-cell lymphomas (104), sporadic B-cell non-Hodgkin's lymphomas (162), undifferentiated nasopharyngeal carcinoma (86), salivary gland lymphoepithelioma (11), and oral hairy leukoplakia (5). "

Related Drugs and Biologics

1.	Brentuximab Vedotin
2.	Immunoconjugates (Immunoconjugate)
3.	Bispecific Antibodies
4.	Chimeric Antigen Receptors
5.	Thyroglobulin
6.	Monoclonal Antibodies
7.	Antigens
8.	IgG Receptors (Fc gamma RI)
9.	Interleukin-2 Receptors (IL 2 Receptor)
10.	Leukocyte Common Antigens (CD45 Antigen)

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy
3.	Transplantation
4.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
5.	Orchiectomy (Orchidectomy)