Immune Serum From Sabin Inactivated Poliovirus Vaccine Immunization Neutralizes Multiple Individual Wild and Vaccine-Derived Polioviruses.

Abstract

BACKGROUND:

A Sabin strain-based inactivated poliomyelitis vaccine (Sabin-IPV) is the rational option for completely eradicating poliovirus transmission. The neutralizing capacity of Sabin-IPV immune serum to different strains of poliovirus is a key indicator of the clinical protective efficacy of this vaccine.

METHODS:

Sera collected from 500 infants enrolled in a randomized, blinded, positive control, phase 2 clinical trial were randomly divided into 5 groups: Groups A, B, and C received high, medium, and low doses, respectively, of Sabin-IPV, while groups D and E received trivalent oral polio vaccine and Salk strain-based IPV, respectively, all on the same schedule. Immune sera were collected after the third dose of primary immunization, and tested in cross-neutralization assays against 19 poliovirus strains of all 3 types.

RESULTS:

All immune sera from all 5 groups interacted with the 19 poliovirus strains with various titers and in a dose-dependent manner. One type 2 immunodeficiency-associated vaccine-derived poliovirus strain was not recognized by these immune sera.

CONCLUSIONS:

Sabin-IPV vaccine can induce protective antibodies against currently circulating and reference wild poliovirus strains and most vaccine-derived poliovirus strains, with rare exceptions.

CLINICAL TRIALS REGISTRATION:

NCT01056705.

• Authors: Mingbo Sun, Changgui Li, Wenbo Xu, Guoyang Liao, Rongcheng Li, Jian Zhou, Yanping Li, Wei Cai, Dongmei Yan, Yanchun Che, Zhifang Ying, Jianfeng Wang, Huijuan Yang, Yan Ma, Lei Ma, Guang Ji, Li Shi, Shude Jiang, Qihan Li
• Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (Clin Infect Dis) Vol. 64 Issue 10 Pg. 1317-1325 (May 15 2017) ISSN: 1537-6591 [Electronic] United States
• PMID: 28419204 (Publication Type: Clinical Trial, Phase II, Journal Article, Randomized Controlled Trial)
• Copyright: © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected].

Chemical References

• Antibodies, Neutralizing
• Antibodies, Viral
• Immune Sera
• Poliovirus Vaccine, Inactivated
• Poliovirus Vaccine, Oral

Topics

• Antibodies, Neutralizing (blood, immunology)
• Antibodies, Viral (blood, immunology)
• Dose-Response Relationship, Immunologic
• Humans
• Immune Sera (immunology)
• Infant
• Neutralization Tests
• Poliomyelitis (prevention & control, transmission, virology)
• Poliovirus (genetics, immunology)
• Poliovirus Vaccine, Inactivated (administration & dosage, immunology)
• Poliovirus Vaccine, Oral (administration & dosage, immunology)
• Sequence Analysis, DNA
• Vaccination