Abstract | BACKGROUND: Continuous intra-arterial (IA) administration of peplomycin (PEP) through a tumor-feeding artery is one of the most effective treatments for cutaneous squamous cell carcinoma (cSCC) in cosmetic areas. PATIENTS AND METHODS: In order to determine the effective and safe dose of PEP and the curative rate of IA-PEP, we retrospectively investigated a case series of 24 patients with cSCC on the lips who were treated with IA-PEP. RESULTS: IA-PEP reduced the tumor mass in all 24 cases (100%). A complete response occurred in 17 patients (70.8%), and a partial response occurred in seven (29.2%). Moreover, 17 patients (70.8%) were cured, three patients developed cervical lymph node metastasis (12.5%), and four developed local recurrence (16.7%). Three out of the 24 patients developed interstitial pneumonia (12.5%). CONCLUSION: Low-dose IA-PEP administered through a superficial temporal artery was a highly effective treatment that achieved a curative response for 70.8% of patients with cSCC on the lips.
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Authors | Taku Fujimura, Kazuhiro Takahashi, Yumi Kambayashi, Sadanori Furudate, Takanori Hidaka, Aya Kakizaki, Akiko Watabe, Takahiro Haga, Akira Hashimoto, Setsuya Aiba |
Journal | Anticancer research
(Anticancer Res)
Vol. 37
Issue 4
Pg. 1885-1889
(04 2017)
ISSN: 1791-7530 [Electronic] Greece |
PMID | 28373456
(Publication Type: Journal Article)
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Copyright | Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved. |
Chemical References |
- Antibiotics, Antineoplastic
- Peplomycin
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Topics |
- Aged
- Aged, 80 and over
- Antibiotics, Antineoplastic
(administration & dosage)
- Carcinoma, Squamous Cell
(drug therapy, pathology)
- Female
- Humans
- Infusions, Intra-Arterial
- Lip Neoplasms
(drug therapy, pathology)
- Male
- Middle Aged
- Neoplasm Staging
- Peplomycin
(administration & dosage)
- Prognosis
- Retrospective Studies
- Skin Neoplasms
(drug therapy, pathology)
- Temporal Arteries
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