Acacia gum polysaccharide based hydrogel wound dressings: Synthesis, characterization, drug delivery and biomedical properties.

Abstract

Keeping in view the importance of polysaccharide gums for wound care, in the present article, an attempt has been made to explore antioxidant nature of gum acacia in designing hydrogel wound dressing to improve its wound healing potential. These polymers were prepared by using acacia gum-polyvinylpyrollidone/carbopol and were characterized by 13C NMR, FTIR, SEM, AFM, cryo-SEM, XRD, TGA, DSC and elemental analysis techniques. Some important biomaterial properties of wound dressings such as wound fluid absorption, haemo-compatibility, bioactive assessment, gaseous/water/microbial permeability, mechanical properties, bio-adhesion, drug release, and histology of wound healing were also determined. Hydrogel wound dressings were found non-haemolytic, antioxidant and mucoadhesive in nature. Release of drug occurred through non-Fickian diffusion mechanism and release profile best fitted in Higuchi model.

• Authors: Baljit Singh, Sushma Sharma, Abhishek Dhiman
• Journal: Carbohydrate polymers (Carbohydr Polym) Vol. 165 Pg. 294-303 (Jun 01 2017) ISSN: 1879-1344 [Electronic] England
• PMID: 28363552 (Publication Type: Journal Article)
• Copyright: Copyright © 2017 Elsevier Ltd. All rights reserved.

Chemical References

• Biocompatible Materials
• Hydrogels
• Polysaccharides
• Gum Arabic

Topics

• Animals
• Bandages
• Biocompatible Materials
• Drug Delivery Systems
• Drug Liberation
• Gum Arabic (chemistry)
• Hydrogels
• Mice, Inbred BALB C
• Polysaccharides (chemistry)