Abstract | BACKGROUND: METHODS: This longitudinal cohort study used the Taiwanese National Health Insurance Research Database (NHIRD) to identify 143,382 newly diagnosed hypertension patients aged 20-90 years who received treatment between 1998 and 2007. Among them, 52,365 (36.52%) had received TCM after the onset of hypertension (TCM users), and the remaining 91,017 patients (63.48%) were designated as a control group (non-TCM users). All enrollees were followed until the end of 2012 to record the incidence of dementia. A Cox proportional hazards regression model was used to compute the hazard ratio (HR) of dementia in patients who received TCM. RESULTS: During the 15-year follow-up, 3933 TCM users and 10,316 non-TCM users developed dementia, representing an incidence rate of 8.41 and 11.55%, respectively, per 1000 person-years. TCM users had a significantly reduced risk of dementia compared to non-TCM users (adjusted HR = 0.76; 95% confidence interval [CI] = 0.74-0.81). The predominant effect was observed among those treated with TCM longer than 180 days (adjusted HR = 0.65; 95% CI = 0.62-0.69). Among the commonly used TCM products, Tian-Ma-Gou-Teng-Yin, Dan-Shen (Radix Salviae Miltiorrhizae), Chuan-Niu-Xi (Radix Cyathulae), Ge-Gen (Radix Puerariae), Jia-Wei-Xiao-Yao-San, and Jue-Ming-Zi (Semen Cassiae) were significantly associated with a lower risk of dementia. CONCLUSIONS: Results from this population-based study support the effects of TCM on reducing dementia risk, which may provide a reference for dementia prevention strategies.
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Authors | Kuen-Hau Chen, Ming-Hsien Yeh, Hanoch Livneh, Bor-Chyuan Chen, I-Hsin Lin, Ming-Chi Lu, Tzung-Yi Tsai, Chia-Chou Yeh |
Journal | BMC complementary and alternative medicine
(BMC Complement Altern Med)
Vol. 17
Issue 1
Pg. 178
(Mar 29 2017)
ISSN: 1472-6882 [Electronic] England |
PMID | 28356117
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Cohort Studies
- Dementia
(complications, drug therapy)
- Drugs, Chinese Herbal
(administration & dosage)
- Female
- Humans
- Hypertension
(complications, drug therapy)
- Longitudinal Studies
- Male
- Medicine, Chinese Traditional
- Middle Aged
- Taiwan
- Young Adult
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