Abstract | BACKGROUND: Limited evidence supports Nigella sativa's role as an effective complementary and alternative medicine and the anti-inflammatory effects of Nigella sativa on patients with allergic rhinitis. OBJECTIVE: METHODS: This study is done as a crossover clinical trial. After obtaining written consent of elderly patients with osteoarthritis of the knee, they were randomly divided into two groups. In step 1, in group 1, 1 cc of Nigella sativa oil was applied on the knee joint every 8 hours for 3 weeks; for the second group, every 8 hours for 3 weeks, patients were given 1 tablet of 325 mg acetaminophen. After a period of 1 month without medication to wash out each group, in step 2, each treatment group received the drug interaction in the same way as above. Pain was determined using a visual scale (VAS) before and after the first and second stages. Treatment response was defined as a decrease in pain scores over 1.5. Data analysis was performed with an R software mixed model. RESULTS: CONCLUSION: The results of this study showed that topical application of Nigella sativa oil was effective in reducing pain in patients with knee osteoarthritis; therefore, it is recommended as a safe supplement for these elderly. TRIAL REGISTRATION: The trial was registered at TCTR (http://www.clinicaltrials.in.th/) with the ID: TCTR20160125003. FUNDING: This study was approved and supported by the Sabzevar University of Medical Sciences.
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Authors | Akram Kooshki, Reza Forouzan, Mohammad Hassan Rakhshani, Maryam Mohammadi |
Journal | Electronic physician
(Electron Physician)
Vol. 8
Issue 11
Pg. 3193-3197
(Nov 2016)
ISSN: 2008-5842 [Print] Iran |
PMID | 28344755
(Publication Type: Journal Article)
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